Novel galanin receptors in teleost fish: Identification, expression and regulation by sex steroids

Highlights • Teleost genomes possess four galanin receptor genes, paralogs of GALR1 and GALR2. • Gene structure and key amino acids were conserved between sea bass and human GALRs. • GALRs are expressed in brain and gonads of adult sea bass. • In pre-pubertal sea bass testis GALR1a and 1b were up re...

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Bibliographic Details
Published in:General and comparative endocrinology 2014-09, Vol.205, p.109-120
Main Authors: Martins, Rute S.T, Pinto, Patrícia I.S, Guerreiro, Pedro M, Zanuy, Silvia, Carrillo, Manuel, Canário, Adelino V.M
Format: Article
Language:English
Subjects:
11-Ketotestosterone
17β-Estradiol
Adolescent
Amino Acid Sequence
Animals
Bass - blood
Bass - genetics
Bass - metabolism
Endocrinology & Metabolism
Galanin receptors
Gene Expression Profiling
Genome - genetics
Gonadal Steroid Hormones - blood
Gonadal Steroid Hormones - metabolism
Humans
Male
Molecular Sequence Data
Phylogeny
Puberty
Receptors, Galanin - chemistry
Receptors, Galanin - genetics
Receptors, Galanin - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sea bass
Sequence Alignment
Sequence Homology, Amino Acid
Steroids - blood
Steroids - metabolism
Synteny
Testis - metabolism
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Description
Summary:Highlights • Teleost genomes possess four galanin receptor genes, paralogs of GALR1 and GALR2. • Gene structure and key amino acids were conserved between sea bass and human GALRs. • GALRs are expressed in brain and gonads of adult sea bass. • In pre-pubertal sea bass testis GALR1a and 1b were up regulated by 11KT but not by E2. • In the brain GALR transcript levels were unaffected by the sex steroid treatments.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.06.030