Establishment of Rat Model of Central Venous Catheter (CVC): Associated Infection and Evaluation of the Virulence of Bacterial Biofilms

In this study, a central venous catheter (CVC)—associated infection model was established in rats to investigate and evaluate the effect of biofilms on the virulence of the pathogens. Twenty-four adult SD rats were randomly divided into biofilm positive (BF+) and biofilm negative (BF−) groups to be...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2014-09, Vol.70 (1), p.429-435
Main Authors: Ye, Lian-Hua, Huang, Yun-Chao, Guo, Feng-Li, Liu, Xin, Zhao, Guang-Qiang, Duan, Lin-Can, Jin, Cong-Guo
Format: Article
Language:English
Subjects:
Animals
Bacteria
Biochemistry
Biofilms
Biofilms - growth & development
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Catheter-Related Infections - blood
Catheter-Related Infections - etiology
Cell Biology
Central Venous Catheters - adverse effects
Central Venous Catheters - microbiology
Cytokines - blood
Disease Models, Animal
Infiltration
Life Sciences
Male
Medical instruments
Organ Specificity
Original Paper
Pharmacology/Toxicology
Rats
Staphylococcal Infections - blood
Staphylococcal Infections - etiology
Staphylococcus epidermidis - pathogenicity
Staphylococcus epidermidis - physiology
Virulence
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Summary:In this study, a central venous catheter (CVC)—associated infection model was established in rats to investigate and evaluate the effect of biofilms on the virulence of the pathogens. Twenty-four adult SD rats were randomly divided into biofilm positive (BF+) and biofilm negative (BF−) groups to be challenged with strains of S.epidermidis . Serum levels of inflammatory cytokines were measured and the infection rate and counts of bacteria cells were studied. Compared to rats of BF− group, the serum level of TNF and IL-6 significantly increased in rats of BF+ group ( P  
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-014-9934-3