Increased levels of anti-heat-shock protein 60 (anti-Hsp60) indicate endothelial dysfunction, atherosclerosis and cardiovascular diseases in patients with mixed connective tissue disease

Heat-shock protein 60 (Hsp60) has been shown to provoke inflammation, and anti-Hsp60 may facilitate the development of atherosclerosis. In this study, we have investigated 30 patients with mixed connective tissue disease (MCTD) and assessed anti-Hsp60 and their relationship to cardiovascular disease...

Full description

Saved in:
Bibliographic Details
Published in:Immunologic research 2014-10, Vol.60 (1), p.50-59
Main Authors: Bodolay, Edit, Prohászka, Zoltan, Paragh, Gyorgy, Csipő, Istvan, Nagy, Gabor, Laczik, Renata, Demeter, Nora, Zöld, Eva, Nakken, Britt, Szegedi, Gyula, Szodoray, Peter
Format: Article
Language:English
Subjects:
Adult
Aged
Allergology
Aryldialkylphosphatase - blood
Atherosclerosis
Autoantibodies - immunology
Biomedical and Life Sciences
Biomedicine
Cardiolipins - immunology
Cardiovascular disease
Cardiovascular Diseases - immunology
Chaperonin 60 - immunology
Endothelin-1 - blood
Female
Heat shock proteins
Humans
Immunoglobulin G - immunology
Immunoglobulins
Immunology
Internal Medicine
Lipids - blood
Lipids - immunology
Male
Medicine/Public Health
Middle Aged
Mixed Connective Tissue Disease - immunology
Tissues
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heat-shock protein 60 (Hsp60) has been shown to provoke inflammation, and anti-Hsp60 may facilitate the development of atherosclerosis. In this study, we have investigated 30 patients with mixed connective tissue disease (MCTD) and assessed anti-Hsp60 and their relationship to cardiovascular diseases (CVD). Out of 30 patients with MCTD, 15 had CVDs. Anti-Hsp60 antibody was determined by enzyme-linked immunosorbent assay. Since endothelial dysfunction and accelerated atherosclerosis are characteristic to MCTD, a wide array of MCTD-, endothelial dysfunction- and CVD-associated parameters was investigated: serum lipid levels, paraoxonase activity (PON1), rich nuclear ribonucleoprotein U1 (anti-U1RNP), anti-endothelial cell antibodies, anti-cardiolipin and anti-β2-glycoprotein I antibody isotypes (anti-CL and anti-β2GPI), endothelin-1 (ET-1) levels, also intima–media thickness (IMT), a quantitative indicator of atherosclerosis. In MCTD, anti-Hsp60 antibody levels were significantly higher than in healthy individuals ( p  
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-014-8552-x