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Pd-Mediated Multicomponent Synthesis of Highly Functionalized Pyridines and Consequential C-C Coupling Using Suzuki Reaction in One Pot: Their In Vitro Evaluation as Potential Antibacterial Agents

Pd‐mediated construction of pyridine scaffold and subsequent Suzuki‐based C—C coupling reaction in one pot has been accomplished for the synthesis of 4‐biaryl substituted 2‐amino‐3‐cyanopyridines via multicomponent reaction. The present multicomponent reaction is useful in structural elaboration of...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2014-08, Vol.51 (S1), p.E104-E113
Main Authors: Srinivasula Reddy, L., Ram Reddy, T., Gangi Reddy, N. C., Mohan, Reddy Bodireddy, Lingappa, Y.
Format: Article
Language:English
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Summary:Pd‐mediated construction of pyridine scaffold and subsequent Suzuki‐based C—C coupling reaction in one pot has been accomplished for the synthesis of 4‐biaryl substituted 2‐amino‐3‐cyanopyridines via multicomponent reaction. The present multicomponent reaction is useful in structural elaboration of pyridine framework and also helpful in design and synthesis of novel and diverse analogs of complex heterocyclic compounds other than present reported molecules. Antibacterial activities of the synthesized compounds were systematically evaluated. The correlation between functional group variation and biological activities of the compounds has been evaluated against human pathogenic gram‐positive and gram‐negative bacterial strains.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1855