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Pd-Mediated Multicomponent Synthesis of Highly Functionalized Pyridines and Consequential C-C Coupling Using Suzuki Reaction in One Pot: Their In Vitro Evaluation as Potential Antibacterial Agents
Pd‐mediated construction of pyridine scaffold and subsequent Suzuki‐based C—C coupling reaction in one pot has been accomplished for the synthesis of 4‐biaryl substituted 2‐amino‐3‐cyanopyridines via multicomponent reaction. The present multicomponent reaction is useful in structural elaboration of...
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| Published in: | Journal of heterocyclic chemistry 2014-08, Vol.51 (S1), p.E104-E113 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3535-2748c3914e01a3d3c0cd5fef5ac687562f968244d265abfe29e022564079923e3 |
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| cites | cdi_FETCH-LOGICAL-c3535-2748c3914e01a3d3c0cd5fef5ac687562f968244d265abfe29e022564079923e3 |
| container_end_page | E113 |
| container_issue | S1 |
| container_start_page | E104 |
| container_title | Journal of heterocyclic chemistry |
| container_volume | 51 |
| creator | Srinivasula Reddy, L. Ram Reddy, T. Gangi Reddy, N. C. Mohan, Reddy Bodireddy Lingappa, Y. |
| description | Pd‐mediated construction of pyridine scaffold and subsequent Suzuki‐based C—C coupling reaction in one pot has been accomplished for the synthesis of 4‐biaryl substituted 2‐amino‐3‐cyanopyridines via multicomponent reaction. The present multicomponent reaction is useful in structural elaboration of pyridine framework and also helpful in design and synthesis of novel and diverse analogs of complex heterocyclic compounds other than present reported molecules. Antibacterial activities of the synthesized compounds were systematically evaluated. The correlation between functional group variation and biological activities of the compounds has been evaluated against human pathogenic gram‐positive and gram‐negative bacterial strains. |
| doi_str_mv | 10.1002/jhet.1855 |
| format | article |
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| ispartof | Journal of heterocyclic chemistry, 2014-08, Vol.51 (S1), p.E104-E113 |
| issn | 0022-152X 1943-5193 |
| language | eng |
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| source | Wiley |
| title | Pd-Mediated Multicomponent Synthesis of Highly Functionalized Pyridines and Consequential C-C Coupling Using Suzuki Reaction in One Pot: Their In Vitro Evaluation as Potential Antibacterial Agents |
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