Appearance of monoclonal plasma cell diseases in whole‐body magnetic resonance imaging and correlation with parameters of disease activity

The aim of our study was to assess in which way different infiltration patterns of monoclonal plasma cell diseases in whole‐body (wb) magnetic resonance imaging (MRI) are associated with clinical stages, plasma cell content in bone marrow samples and established serum markers of disease activity. In...

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Bibliographic Details
Published in:International journal of cancer 2014-11, Vol.135 (10), p.2380-2386
Main Authors: Kloth, Jost K., Hillengass, Jens, Listl, Karin, Kilk, Kerstin, Hielscher, Thomas, Landgren, Ola, Delorme, Stefan, Goldschmidt, Hartmut, Kauczor, Hans‐Ulrich, Weber, Marc‐André
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Bone marrow
Bone Marrow - metabolism
Bone Marrow - pathology
Cancer
correlation analysis
Disease
disease activity
Disease Progression
Female
Follow-Up Studies
Humans
Image Processing, Computer-Assisted
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical research
Middle Aged
Monoclonal Gammopathy of Undetermined Significance - metabolism
Monoclonal Gammopathy of Undetermined Significance - pathology
monoclonal plasma cell disease
Multiple myeloma
Multiple Myeloma - metabolism
Multiple Myeloma - pathology
Myeloma Proteins - metabolism
Neoplasm Staging
NMR
Nuclear magnetic resonance
Plasma
Plasma Cells - metabolism
Plasma Cells - pathology
Prognosis
Retrospective Studies
Whole Body Imaging
Young Adult
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Summary:The aim of our study was to assess in which way different infiltration patterns of monoclonal plasma cell diseases in whole‐body (wb) magnetic resonance imaging (MRI) are associated with clinical stages, plasma cell content in bone marrow samples and established serum markers of disease activity. Institutional review board approval was obtained. We performed wb‐MRI in 547 consecutive, unselected and untreated patients with monoclonal gammopathy of undetermined significance (MGUS, n = 138), smoldering myeloma (SMM, n = 157) and multiple myeloma (MM, n = 252) on two 1.5 T MRI‐scanners with body array coils. The studies were evaluated in consensus by two experienced radiologists blinded to the diagnosis. We observed focal lesions in 23.9% (MGUS), 34.4% (SMM) and 81.3% (MM), respectively. A diffuse infiltration pattern was detected in 38.4%, 45.9% and 71%, respectively. The differences between all infiltration patterns were significant (p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.28877