Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)

Background and Aim The serpin squamous cell carcinoma antigen complexed with IgM (SCCA‐IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA‐IgM diagnostic accuracy and to determine its prognostic role. Methods SCCA‐IgM levels...

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Published in:Journal of gastroenterology and hepatology 2014-08, Vol.29 (8), p.1637-1644
Main Authors: Pozzan, Caterina, Cardin, Romilda, Piciocchi, Marika, Cazzagon, Nora, Maddalo, Gemma, Vanin, Veronica, Giacomin, Anna, Pontisso, Patrizia, Cillo, Umberto, Farinati, Fabio
Format: Article
Language:English
Subjects:
Aged
Antigens, Neoplasm - blood
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - mortality
diagnosis
Disease-Free Survival
Female
hepatocellular carcinoma
Humans
Immunoglobulin M - blood
Liver Neoplasms - diagnosis
Liver Neoplasms - mortality
Male
Middle Aged
Predictive Value of Tests
Prognosis
SCCA-IgM
Sensitivity and Specificity
serological biomarkers
Serpins - blood
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Summary:Background and Aim The serpin squamous cell carcinoma antigen complexed with IgM (SCCA‐IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA‐IgM diagnostic accuracy and to determine its prognostic role. Methods SCCA‐IgM levels were determined in 327 sera obtained from 81 HCC patients, 206 cirrhotics and 40 healthy blood donors (controls). Sensitivity, specificity, correlation with clinical and tumor parameters and with survival were evaluated. Results HCC patients had SCCA‐IgM levels significantly higher than controls and cirrhotics (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.12576