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Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)
Background and Aim The serpin squamous cell carcinoma antigen complexed with IgM (SCCA‐IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA‐IgM diagnostic accuracy and to determine its prognostic role. Methods SCCA‐IgM levels...
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| Published in: | Journal of gastroenterology and hepatology 2014-08, Vol.29 (8), p.1637-1644 |
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| Main Authors: | , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c4626-f052c627c4203ac9b8781613685aab292f8e7160a69f7c26d090ce5ef035e5d83 |
| container_end_page | 1644 |
| container_issue | 8 |
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| container_title | Journal of gastroenterology and hepatology |
| container_volume | 29 |
| creator | Pozzan, Caterina Cardin, Romilda Piciocchi, Marika Cazzagon, Nora Maddalo, Gemma Vanin, Veronica Giacomin, Anna Pontisso, Patrizia Cillo, Umberto Farinati, Fabio |
| description | Background and Aim
The serpin squamous cell carcinoma antigen complexed with IgM (SCCA‐IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA‐IgM diagnostic accuracy and to determine its prognostic role.
Methods
SCCA‐IgM levels were determined in 327 sera obtained from 81 HCC patients, 206 cirrhotics and 40 healthy blood donors (controls). Sensitivity, specificity, correlation with clinical and tumor parameters and with survival were evaluated.
Results
HCC patients had SCCA‐IgM levels significantly higher than controls and cirrhotics (P |
| doi_str_mv | 10.1111/jgh.12576 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566847051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1550078282</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4626-f052c627c4203ac9b8781613685aab292f8e7160a69f7c26d090ce5ef035e5d83</originalsourceid><addsrcrecordid>eNqNkEtPGzEURq2qqITAon-g8hIWA9f2-DFLNJQkKFAhHlW7sRznThg6j9TO8Pj3DISwq9S7ubrS-T5dHUK-Mjhk_RzdL-4OGZdafSIDlqaQMJ2qz2QAhskkEyzbJjsx3gNAClp-Ids8VUKCMAPy66R0i6aNq9JT18zpMrSbM7QV0ragV3l-nEwW5zRi6Gpa4QNWkZYNvcOlW7Ueq6qrXKDeBV82be3o_jjPD3bJVuGqiHvve0huTr9f5-Nk-mM0yY-niU8VV0kBknvFtU85COezmdGGKSaUkc7NeMYLg5opcCortOdqDhl4lFiAkCjnRgzJ_rq3f_1vh3Fl6zK-PuUabLtomVTKpBok-w9UAmjDDe_RgzXqQxtjwMIuQ1m78GwZ2Ffptpdu36T37Lf32m5W4_yD3FjugaM18FhW-PzvJns2Gm8qk3WijCt8-ki48McqLbS0Py9G9vdtdn05HUl7JV4AsqaYLA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1550078282</pqid></control><display><type>article</type><title>Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Pozzan, Caterina ; Cardin, Romilda ; Piciocchi, Marika ; Cazzagon, Nora ; Maddalo, Gemma ; Vanin, Veronica ; Giacomin, Anna ; Pontisso, Patrizia ; Cillo, Umberto ; Farinati, Fabio</creator><creatorcontrib>Pozzan, Caterina ; Cardin, Romilda ; Piciocchi, Marika ; Cazzagon, Nora ; Maddalo, Gemma ; Vanin, Veronica ; Giacomin, Anna ; Pontisso, Patrizia ; Cillo, Umberto ; Farinati, Fabio</creatorcontrib><description>Background and Aim
The serpin squamous cell carcinoma antigen complexed with IgM (SCCA‐IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA‐IgM diagnostic accuracy and to determine its prognostic role.
Methods
SCCA‐IgM levels were determined in 327 sera obtained from 81 HCC patients, 206 cirrhotics and 40 healthy blood donors (controls). Sensitivity, specificity, correlation with clinical and tumor parameters and with survival were evaluated.
Results
HCC patients had SCCA‐IgM levels significantly higher than controls and cirrhotics (P < 0.0001). Sensitivity, specificity, positive and negative predictive values for HCC were 89%, 50%, 41% and 92%, respectively. In comparison, sensitivity and specificity for alphafetoprotein were 48% and 85%. SCCA‐IgM levels were not significantly correlated with clinical or biological variables. With a cut‐off of 130 AU/mL (receiver operating characteristic curves), SCCA‐IgM proved efficient in the prediction of prognosis, identifying the patients with long overall survival (efficiency validated in the homogenous subgroup of patients with intermediate‐stage HCC undergoing transarterial chemoembolization) and predicting progression‐free survival. A Cox multivariate analysis confirmed SCCA‐IgM predictive value, identifying tumor size and SCCA‐IgM levels as independent predictors of survival. A reduction in SCCA‐IgM levels correlated with response to treatment.
Conclusions
SCCA‐IgM is a sensitive marker of HCC in patients with cirrhosis even though lacking in specificity. The determination of the levels of the marker in HCC patients is highly efficient in predicting the patients' prognosis, identifying those with long overall and progression‐free survival and the responders and should be introduced in the clinical practice.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.12576</identifier><identifier>PMID: 24635038</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Aged ; Antigens, Neoplasm - blood ; Biomarkers, Tumor - blood ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - mortality ; diagnosis ; Disease-Free Survival ; Female ; hepatocellular carcinoma ; Humans ; Immunoglobulin M - blood ; Liver Neoplasms - diagnosis ; Liver Neoplasms - mortality ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; SCCA-IgM ; Sensitivity and Specificity ; serological biomarkers ; Serpins - blood</subject><ispartof>Journal of gastroenterology and hepatology, 2014-08, Vol.29 (8), p.1637-1644</ispartof><rights>2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd</rights><rights>2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4626-f052c627c4203ac9b8781613685aab292f8e7160a69f7c26d090ce5ef035e5d83</citedby><cites>FETCH-LOGICAL-c4626-f052c627c4203ac9b8781613685aab292f8e7160a69f7c26d090ce5ef035e5d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24635038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pozzan, Caterina</creatorcontrib><creatorcontrib>Cardin, Romilda</creatorcontrib><creatorcontrib>Piciocchi, Marika</creatorcontrib><creatorcontrib>Cazzagon, Nora</creatorcontrib><creatorcontrib>Maddalo, Gemma</creatorcontrib><creatorcontrib>Vanin, Veronica</creatorcontrib><creatorcontrib>Giacomin, Anna</creatorcontrib><creatorcontrib>Pontisso, Patrizia</creatorcontrib><creatorcontrib>Cillo, Umberto</creatorcontrib><creatorcontrib>Farinati, Fabio</creatorcontrib><title>Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
The serpin squamous cell carcinoma antigen complexed with IgM (SCCA‐IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA‐IgM diagnostic accuracy and to determine its prognostic role.
Methods
SCCA‐IgM levels were determined in 327 sera obtained from 81 HCC patients, 206 cirrhotics and 40 healthy blood donors (controls). Sensitivity, specificity, correlation with clinical and tumor parameters and with survival were evaluated.
Results
HCC patients had SCCA‐IgM levels significantly higher than controls and cirrhotics (P < 0.0001). Sensitivity, specificity, positive and negative predictive values for HCC were 89%, 50%, 41% and 92%, respectively. In comparison, sensitivity and specificity for alphafetoprotein were 48% and 85%. SCCA‐IgM levels were not significantly correlated with clinical or biological variables. With a cut‐off of 130 AU/mL (receiver operating characteristic curves), SCCA‐IgM proved efficient in the prediction of prognosis, identifying the patients with long overall survival (efficiency validated in the homogenous subgroup of patients with intermediate‐stage HCC undergoing transarterial chemoembolization) and predicting progression‐free survival. A Cox multivariate analysis confirmed SCCA‐IgM predictive value, identifying tumor size and SCCA‐IgM levels as independent predictors of survival. A reduction in SCCA‐IgM levels correlated with response to treatment.
Conclusions
SCCA‐IgM is a sensitive marker of HCC in patients with cirrhosis even though lacking in specificity. The determination of the levels of the marker in HCC patients is highly efficient in predicting the patients' prognosis, identifying those with long overall and progression‐free survival and the responders and should be introduced in the clinical practice.</description><subject>Aged</subject><subject>Antigens, Neoplasm - blood</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>diagnosis</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Immunoglobulin M - blood</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>SCCA-IgM</subject><subject>Sensitivity and Specificity</subject><subject>serological biomarkers</subject><subject>Serpins - blood</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkEtPGzEURq2qqITAon-g8hIWA9f2-DFLNJQkKFAhHlW7sRznThg6j9TO8Pj3DISwq9S7ubrS-T5dHUK-Mjhk_RzdL-4OGZdafSIDlqaQMJ2qz2QAhskkEyzbJjsx3gNAClp-Ids8VUKCMAPy66R0i6aNq9JT18zpMrSbM7QV0ragV3l-nEwW5zRi6Gpa4QNWkZYNvcOlW7Ueq6qrXKDeBV82be3o_jjPD3bJVuGqiHvve0huTr9f5-Nk-mM0yY-niU8VV0kBknvFtU85COezmdGGKSaUkc7NeMYLg5opcCortOdqDhl4lFiAkCjnRgzJ_rq3f_1vh3Fl6zK-PuUabLtomVTKpBok-w9UAmjDDe_RgzXqQxtjwMIuQ1m78GwZ2Ffptpdu36T37Lf32m5W4_yD3FjugaM18FhW-PzvJns2Gm8qk3WijCt8-ki48McqLbS0Py9G9vdtdn05HUl7JV4AsqaYLA</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Pozzan, Caterina</creator><creator>Cardin, Romilda</creator><creator>Piciocchi, Marika</creator><creator>Cazzagon, Nora</creator><creator>Maddalo, Gemma</creator><creator>Vanin, Veronica</creator><creator>Giacomin, Anna</creator><creator>Pontisso, Patrizia</creator><creator>Cillo, Umberto</creator><creator>Farinati, Fabio</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201408</creationdate><title>Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)</title><author>Pozzan, Caterina ; Cardin, Romilda ; Piciocchi, Marika ; Cazzagon, Nora ; Maddalo, Gemma ; Vanin, Veronica ; Giacomin, Anna ; Pontisso, Patrizia ; Cillo, Umberto ; Farinati, Fabio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4626-f052c627c4203ac9b8781613685aab292f8e7160a69f7c26d090ce5ef035e5d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Antigens, Neoplasm - blood</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>diagnosis</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Immunoglobulin M - blood</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>SCCA-IgM</topic><topic>Sensitivity and Specificity</topic><topic>serological biomarkers</topic><topic>Serpins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pozzan, Caterina</creatorcontrib><creatorcontrib>Cardin, Romilda</creatorcontrib><creatorcontrib>Piciocchi, Marika</creatorcontrib><creatorcontrib>Cazzagon, Nora</creatorcontrib><creatorcontrib>Maddalo, Gemma</creatorcontrib><creatorcontrib>Vanin, Veronica</creatorcontrib><creatorcontrib>Giacomin, Anna</creatorcontrib><creatorcontrib>Pontisso, Patrizia</creatorcontrib><creatorcontrib>Cillo, Umberto</creatorcontrib><creatorcontrib>Farinati, Fabio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pozzan, Caterina</au><au>Cardin, Romilda</au><au>Piciocchi, Marika</au><au>Cazzagon, Nora</au><au>Maddalo, Gemma</au><au>Vanin, Veronica</au><au>Giacomin, Anna</au><au>Pontisso, Patrizia</au><au>Cillo, Umberto</au><au>Farinati, Fabio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2014-08</date><risdate>2014</risdate><volume>29</volume><issue>8</issue><spage>1637</spage><epage>1644</epage><pages>1637-1644</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
The serpin squamous cell carcinoma antigen complexed with IgM (SCCA‐IgM) has been reported as a promising serological marker for hepatocellular carcinoma (HCC). We aimed to further evaluate SCCA‐IgM diagnostic accuracy and to determine its prognostic role.
Methods
SCCA‐IgM levels were determined in 327 sera obtained from 81 HCC patients, 206 cirrhotics and 40 healthy blood donors (controls). Sensitivity, specificity, correlation with clinical and tumor parameters and with survival were evaluated.
Results
HCC patients had SCCA‐IgM levels significantly higher than controls and cirrhotics (P < 0.0001). Sensitivity, specificity, positive and negative predictive values for HCC were 89%, 50%, 41% and 92%, respectively. In comparison, sensitivity and specificity for alphafetoprotein were 48% and 85%. SCCA‐IgM levels were not significantly correlated with clinical or biological variables. With a cut‐off of 130 AU/mL (receiver operating characteristic curves), SCCA‐IgM proved efficient in the prediction of prognosis, identifying the patients with long overall survival (efficiency validated in the homogenous subgroup of patients with intermediate‐stage HCC undergoing transarterial chemoembolization) and predicting progression‐free survival. A Cox multivariate analysis confirmed SCCA‐IgM predictive value, identifying tumor size and SCCA‐IgM levels as independent predictors of survival. A reduction in SCCA‐IgM levels correlated with response to treatment.
Conclusions
SCCA‐IgM is a sensitive marker of HCC in patients with cirrhosis even though lacking in specificity. The determination of the levels of the marker in HCC patients is highly efficient in predicting the patients' prognosis, identifying those with long overall and progression‐free survival and the responders and should be introduced in the clinical practice.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>24635038</pmid><doi>10.1111/jgh.12576</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of gastroenterology and hepatology, 2014-08, Vol.29 (8), p.1637-1644 |
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| subjects | Aged Antigens, Neoplasm - blood Biomarkers, Tumor - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - mortality diagnosis Disease-Free Survival Female hepatocellular carcinoma Humans Immunoglobulin M - blood Liver Neoplasms - diagnosis Liver Neoplasms - mortality Male Middle Aged Predictive Value of Tests Prognosis SCCA-IgM Sensitivity and Specificity serological biomarkers Serpins - blood |
| title | Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC) |
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