Circulating tumour cells and circulating free nucleic acid as prognostic and predictive biomarkers in colorectal cancer

Abstract The detection of circulating tumour cells or circulating free tumour nucleic acids can potentially guide treatment and inform prognosis in colorectal cancer using minimally invasive “liquid biopsies”. Current literature supports the notion that high circulating tumour cell counts or presenc...

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Bibliographic Details
Published in:Cancer letters 2014-04, Vol.346 (1), p.24-33
Main Authors: Lim, S.H, Becker, T.M, Chua, W, Caixeiro, N.J, Ng, W.L, Kienzle, N, Tognela, A, Lumba, S, Rasko, J.E.J, de Souza, P, Spring, K.J
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor - blood
Breast cancer
Cancer therapies
Cell adhesion & migration
Circulating free DNA
Circulating free RNA
Circulating tumour cells
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Deoxyribonucleic acid
DNA
DNA - analysis
DNA - blood
Hematology, Oncology and Palliative Medicine
Humans
Medical prognosis
Neoplastic Cells, Circulating
Patients
Personalised cancer therapy
Prognosis
RNA - analysis
RNA - blood
Studies
Surgery
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Summary:Abstract The detection of circulating tumour cells or circulating free tumour nucleic acids can potentially guide treatment and inform prognosis in colorectal cancer using minimally invasive “liquid biopsies”. Current literature supports the notion that high circulating tumour cell counts or presence of tumour nucleic acid correlate with inferior clinical outcomes for patients, but they are not yet part of routine clinical care. Future research evolves around the examination of the molecular phenotype of circulating tumour cells. The key unanswered areas include differentiating between circulating tumour cell presence and their proliferative capacity and dormancy, identifying tumour heterogeneity and understanding the epithelial–mesenchymal transition.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.12.019