Increased levels and adipose tissue expression of visfatin in morbidly obese women: the relationship with pro-inflammatory cytokines

Summary Objective  The controversial results on the physiopathological role of visfatin led us to examine both circulating visfatin levels and gene expression in visceral (VAT) and subcutaneous fat (SAT) in a homogeneous group of morbidly obese women. Design, patients and measurements  We analysed c...

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Published in:Clinical endocrinology (Oxford) 2012-11, Vol.77 (5), p.691-698
Main Authors: Terra, Ximena, Auguet, Teresa, Quesada, Isabel, Aguilar, Carmen, Luna, Anna Maria, Hernández, Mercé, Sabench, Fátima, Porras, José Antonio, Martínez, Salomé, Lucas, Anna, Pellitero, Silvia, Llutart, Jordi, del Castillo, Daniel, Richart, Cristóbal
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adult
Biological and medical sciences
Cytokines - metabolism
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Interleukin-6 - metabolism
Intra-Abdominal Fat - metabolism
Medical sciences
Metabolic diseases
Middle Aged
Nicotinamide Phosphoribosyltransferase - metabolism
Obesity
Obesity, Morbid - metabolism
Real-Time Polymerase Chain Reaction
Subcutaneous Fat - metabolism
Tumor Necrosis Factor-alpha - metabolism
Vertebrates: endocrinology
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Summary:Summary Objective  The controversial results on the physiopathological role of visfatin led us to examine both circulating visfatin levels and gene expression in visceral (VAT) and subcutaneous fat (SAT) in a homogeneous group of morbidly obese women. Design, patients and measurements  We analysed circulating levels of several adipo/cytokines in 133 Spanish women: 40 lean (C) [body mass index (BMI)  40 kg/m2). In the MO group, we found 31 diabetic and 62 nondiabetic subjects. We obtained follow‐up blood samples at 6 and 12 months after bariatric surgery from 30 MO patients. We determined the circulating levels of visfatin, adiponectin, interleukin‐6 (IL6), C‐reactive protein (CRP), resistin and tumour necrosis factor‐α (TNFα) by ELISA, and visfatin, adiponectin, IL6, resistin and TNFα gene expression in SAT and VAT by real‐time RT‐PCR. Results  Circulating visfatin levels were higher in MO women compared with lean controls (C = 1·43 ± 0·14 μg/l, MO = 3·60 ± 0·29 μg/l, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2011.04327.x