Prenatal exposure to selective serotonin reuptake inhibitors and social responsiveness symptoms of autism: population-based study of young children

• Published in: British journal of psychiatry 2014-08, Vol.205 (2), p.95-102
• Main Authors: Marroun, Hanan El, White, Tonya J. H., van der Knaap, Noortje J. F., Homberg, Judith R., Fernández, Guillén, Schoemaker, Nikita K., Jaddoe, Vincent W. V., Hofman, Albert, Verhulst, Frank C., Hudziak, James J., Stricker, Bruno H. C., Tiemeier, Henning
• Format: Article
• Language: English
• Subjects: Antidepressants; Autism; Autistic children; Autistic Disorder - chemically induced; Biological and medical sciences; Brain research; Child & adolescent psychiatry; Child Behavior Checklist; Child clinical studies; Childhood; Children; Children & youth; Depressive Disorder - drug therapy; Developmental delays; Developmental disorders; Epidemiology; Female; Humans; Infantile autism; Maternal depression; Medical sciences; Mental depression; Neonatal abstinence syndrome; Neurosciences; Pharmacovigilance; Pharmacy; Population; Population studies; Population-based studies; Postpartum depression; Pregnancy; Prenatal care; Prenatal experience; Prenatal exposure; Prenatal Exposure Delayed Effects - chemically induced; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Questionnaires; Responsiveness; Serotonin; Serotonin reuptake inhibitors; Serotonin uptake inhibitors; Serotonin Uptake Inhibitors - adverse effects; Uterus
• ISSN: 0007-1250; 1472-1465
• DOI: 10.1192/bjp.bp.113.127746

Selective serotonin reuptake inhibitors (SSRIs) are considered safe and are frequently used during pregnancy. However, two case-control studies suggested an association between prenatal SSRI exposure with childhood autism. To prospectively determine whether intra-uterine SSSRI exposure is associated with childhood autistic symptoms in a population-based study. A total of 376 children prenatally exposed to maternal depressive symptoms (no SSRI exposure), 69 children prenatally exposed to SSRIs and 5531 unexposed children were included. Child pervasive developmental and affective problems were assessed by parental report with the Child Behavior Checklist at ages 1.5, 3 and 6. At age 6, we assessed autistic traits using the Social Responsiveness Scale (n = 4264). Prenatal exposure to maternal depressive symptoms without SSRIs was related to both pervasive developmental (odds ratio (OR) = 1.44, 95% CI 1.07-1.93) and affective problems (OR = 1.44, 95% CI 1.15-1.81). Compared with unexposed children, those prenatally exposed to SSRIs also were at higher risk for developing pervasive developmental problems (OR = 1.91, 95% CI 1.13-3.47), but not for affective problems. Children prenatally exposed to SSRIs also had more autistic traits (B = 0.15, 95% CI 0.08-0.22) compared with those exposed to depressive symptoms only. Our results suggest an association between prenatal SSRI exposure and autistic traits in children. Prenatal depressive symptoms without SSRI use were also associated with autistic traits, albeit this was weaker and less specific. Long-term drug safety trials are needed before evidence-based recommendations are possible.