CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients

To investigate whether CCR5 deletion is associated with susceptibility to Behçet's disease (BD) in a Portuguese population. A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental rheumatology 2014-07, Vol.32 (4 Suppl 84), p.S72-S74
Main Authors: Bettencourt, Andreia, Leal, Bárbara, Carvalho, Cláudia, Oliveira, Rita, Martins Silva, Ana, Vaz Patto, José, Bastos, Marina, Costa, Luciana, Costa, Paulo P, Vasconcelos, Carlos, Correia, João, Silva, Berta M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Behcet Syndrome - genetics
Behcet Syndrome - metabolism
Female
Gene Deletion
Genetic Predisposition to Disease - genetics
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Portugal
Receptors, CCR5 - genetics
Receptors, CCR5 - metabolism
Signal Transduction - genetics
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate whether CCR5 deletion is associated with susceptibility to Behçet's disease (BD) in a Portuguese population. A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing. No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences. These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.
ISSN:0392-856X