Mixed-ligand metal complexes containing an ONS Schiff base and imidazole/benzimidazole ligands: synthesis, characterization, crystallography and biological activity

Salicylaldehyde-4-methylthiosemicarbazone (H 2 MTSali) has been prepared via the condensation reaction of 4-methyl-3-thiosemicarbazide and salicylaldehyde. Four new mixed-ligand copper(II) and nickel(II) complexes with a general formula [M(MTSali)L] (M = Cu 2+ or Ni 2+ ; L = co-ligand) were synthesi...

Full description

Saved in:
Bibliographic Details
Published in:Transition metal chemistry (Weinheim) 2014-09, Vol.39 (6), p.633-639
Main Authors: Mazlan, Nurul Ain, Ravoof, Thahira Begum S. A., Tiekink, Edward R. T., Tahir, Mohamed Ibrahim Mohamed, Veerakumarasivam, Abhi, Crouse, Karen A.
Format: Article
Language:English
Subjects:
Atomic beam spectroscopy
Breast
Catalysis
Chemistry
Chemistry and Materials Science
Crystallography
Imidazole
Inorganic Chemistry
Ligands
Nitrous oxides
Organometallic Chemistry
Physical Chemistry
Schiff bases
Spectroscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Salicylaldehyde-4-methylthiosemicarbazone (H 2 MTSali) has been prepared via the condensation reaction of 4-methyl-3-thiosemicarbazide and salicylaldehyde. Four new mixed-ligand copper(II) and nickel(II) complexes with a general formula [M(MTSali)L] (M = Cu 2+ or Ni 2+ ; L = co-ligand) were synthesized, where L is either imidazole (im) or benzimidazole (bzim). The Schiff base and its mixed-ligand complexes were characterized by IR and UV/Vis spectroscopy, and the complexes by molar conductivity and magnetic susceptibility measurements. The spectroscopic data indicated that the Schiff base behaves as a tridentate ONS donor ligand coordinating via the phenoxide-oxygen, azomethine-nitrogen, and thiolate-sulphur atoms. Magnetic data indicate a square planar environment for the nickel(II) complexes while molar conductance values indicate that the metal complexes are essentially non-electrolytes in DMSO solution. X-ray crystallography shows Cu(MTSali)bzim ( 1 ) and Ni(MTSali)bzim ( 3 ) to be isostructural, with the metal(II) ions being coordinated by a N 2 OS donor set that defines an approximate square planar geometry; in both cases, the benzimidazole is splayed with respect to the coordination plane. The copper(II) complexes were active against MDA-MB-231 and MCF-7 breast cancer cell lines, more so than H 2 MTSali, whereas the nickel(II) complexes were inactive.
ISSN:0340-4285
1572-901X
DOI:10.1007/s11243-014-9842-9