Detection and recognition of cancer cells in vivo

A fundamentally new recognition method of bio-objects (e.g., cancer cells as the most important case of them) that escape the immune system supervision control is suggested. It is proposed to use a unified complex consisting of several molecular groups (e.g., antibodies or their fragments) bound wit...

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Bibliographic Details
Published in:Physics letters. A 2013-10, Vol.377 (25-27), p.1627-1630
Main Authors: Namiot, V.A., Kogan, E.A.
Format: Article
Language:English
Subjects:
Biomedical materials
Cancer
Escape systems
Immune systems
In vivo testing
In vivo tests
Modern principles of multitarget anticancer therapy
Nano-device
Recognition
Solid state physics
Surface signalling molecules
Tumour profiling
Tumour signature
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Summary:A fundamentally new recognition method of bio-objects (e.g., cancer cells as the most important case of them) that escape the immune system supervision control is suggested. It is proposed to use a unified complex consisting of several molecular groups (e.g., antibodies or their fragments) bound with each other. Binding targets are localized on the surface of this bio-object. The choice of the targets is determined by antigen profiling being expressed on the surface of these bio-objects. The recognition efficiency appears to be notably higher than in a situation when molecular groups do not form a unified complex and act separately.
ISSN:0375-9601
1873-2429
DOI:10.1016/j.physleta.2013.04.046