A sensitive voltammetric sensor based on synergistic effect of graphene-polyaniline hybrid film for quantification of calcium antagonist lercanidipine

ABSTRACT A chemically modified sensor based on the synergistic effect of graphene and polyaniline for electrochemical sensing of calcium antagonist lercanidipine (LCP) has been developed. Scanning electron microscopy, electrochemical impedance spectroscopy, square‐wave voltammetry, and cyclic voltam...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied polymer science 2014-11, Vol.131 (21), p.np-n/a
Main Authors: Jain, Rajeev, Tiwari, Dinesh Chandra, Shrivastava, Swati
Format: Article
Language:English
Subjects:
Analysis
Applied sciences
Biological and medical sciences
Calcium
Composites
conducting polymers
Electrochemical impedance spectroscopy
Exact sciences and technology
Forms of application and semi-finished materials
General pharmacology
Graphene
graphene and fullerenes
Liquid crystal polymers
Materials science
Medical sciences
nanotubes
Pharmacology. Drug treatments
Polymer industry, paints, wood
Polymers
Reduction
Sensors
sensors and actuators
Synergistic effect
Technology of polymers
Voltammetry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT A chemically modified sensor based on the synergistic effect of graphene and polyaniline for electrochemical sensing of calcium antagonist lercanidipine (LCP) has been developed. Scanning electron microscopy, electrochemical impedance spectroscopy, square‐wave voltammetry, and cyclic voltammetry were utilized to characterize the morphology and electroanalytical performance of the fabricated sensor. Under optimized conditions, reduction peak current was linear over the wide concentration range from 5 to 125 ng mL−1 with correlation coefficient of 0.9998. The limit of detection and the limit of quantification were found to be 1.94 and 5.89 ng mL−1. The developed sensor also exhibited good reproducibility and long‐term stability. In addition, the proposed method was successfully applied to the determination of LCP in pharmaceutical formulation which is proved by recovery studies. Graphene–polyaniline composites are expected to be promising material for biosensing applications because of the ease of fabrication, excellent electrochemical performance, and high electroactive surface area. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40959.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.40959