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Correlation between clastogenicity and promotion activity in liver carcinogenesis by N-hydroxy-2-acetylaminofluorene, N-hydroxy-4'-fluoro-4-acetylaminobiphenyl and N-hydroxy-4-acetylaminobiphenyl

N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt—Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP s...

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Published in:Carcinogenesis (New York) 1990-02, Vol.11 (2), p.333-339
Main Authors: van de Poll, Monique L.M., van der Hulst, Dolinda A.M., Tates, Ad D., Meerman, John H.N.
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van der Hulst, Dolinda A.M.
Tates, Ad D.
Meerman, John H.N.
description N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt—Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiation capacity when administered to male Wistar rats at a dose of 30, 120 and 120 μmol/kg respectively, 24 h after a two-thirds partial hepatectomy (PH). In contrast, only N-OH-AAF was very effective as promoter when administered to rats previously initiated with diethylnitrosamine. This was evidenced by a high number of large γ-glutamyltrans-peptidase-positive (GGT+) foci occupying a high percentage (22%.) of liver volume. N-OH-FAABP was a much weaker promoter, resulting in smaller foci and lower percentage (4%.) of GGT+ liver volume. The incomplete carcinogen N-OH-AABP was totally ineffective as promoter in our model. A similar difference was seen in the clastogenicity of these carcinogens in rat liver in vivo as measured by the formation of micronuclei: N-OH-AAF was far more clastogenic than N-OH-FAABP, which in turn was more clastogenic than N-OH-AABP. We have recently shown that N-acetylated deoxyguanosine adducts are responsible for clastogenicity of N-OH-AAF and may be important for promotion. DNA adduct analysis after injection of 120 μmol/kg of tritium-labeled N-OH-FAABP or N-OH-AABP, 24 h after PH, showed that N-acetylated adducts to C8 of deoxyguanosine are also formed from these structurally related liver carcinogens. However, the formation of these adducts from N-OH-FAABP and N-OH-AABP was ∼ 8 and ∼ 5% of the formation of dG-C8-AAF after injection of 25 μmol/kg N-OH-AAF. These data show that for the structurally related liver carcinogens N-OH-AAF, N-OH-FAABP and N-OH-AABP, clastogenicity does not predict initiating efficacy but correlates with promotion activity. Possibly, N-acetylated adducts to C8 of deoxyguanosine are involved in both clastogenicity and promotion.
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N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiation capacity when administered to male Wistar rats at a dose of 30, 120 and 120 μmol/kg respectively, 24 h after a two-thirds partial hepatectomy (PH). In contrast, only N-OH-AAF was very effective as promoter when administered to rats previously initiated with diethylnitrosamine. This was evidenced by a high number of large γ-glutamyltrans-peptidase-positive (GGT+) foci occupying a high percentage (22%.) of liver volume. N-OH-FAABP was a much weaker promoter, resulting in smaller foci and lower percentage (4%.) of GGT+ liver volume. The incomplete carcinogen N-OH-AABP was totally ineffective as promoter in our model. A similar difference was seen in the clastogenicity of these carcinogens in rat liver in vivo as measured by the formation of micronuclei: N-OH-AAF was far more clastogenic than N-OH-FAABP, which in turn was more clastogenic than N-OH-AABP. 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N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiation capacity when administered to male Wistar rats at a dose of 30, 120 and 120 μmol/kg respectively, 24 h after a two-thirds partial hepatectomy (PH). In contrast, only N-OH-AAF was very effective as promoter when administered to rats previously initiated with diethylnitrosamine. This was evidenced by a high number of large γ-glutamyltrans-peptidase-positive (GGT+) foci occupying a high percentage (22%.) of liver volume. N-OH-FAABP was a much weaker promoter, resulting in smaller foci and lower percentage (4%.) of GGT+ liver volume. The incomplete carcinogen N-OH-AABP was totally ineffective as promoter in our model. A similar difference was seen in the clastogenicity of these carcinogens in rat liver in vivo as measured by the formation of micronuclei: N-OH-AAF was far more clastogenic than N-OH-FAABP, which in turn was more clastogenic than N-OH-AABP. We have recently shown that N-acetylated deoxyguanosine adducts are responsible for clastogenicity of N-OH-AAF and may be important for promotion. DNA adduct analysis after injection of 120 μmol/kg of tritium-labeled N-OH-FAABP or N-OH-AABP, 24 h after PH, showed that N-acetylated adducts to C8 of deoxyguanosine are also formed from these structurally related liver carcinogens. However, the formation of these adducts from N-OH-FAABP and N-OH-AABP was ∼ 8 and ∼ 5% of the formation of dG-C8-AAF after injection of 25 μmol/kg N-OH-AAF. These data show that for the structurally related liver carcinogens N-OH-AAF, N-OH-FAABP and N-OH-AABP, clastogenicity does not predict initiating efficacy but correlates with promotion activity. Possibly, N-acetylated adducts to C8 of deoxyguanosine are involved in both clastogenicity and promotion.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2302760</pmid><doi>10.1093/carcin/11.2.333</doi><tpages>7</tpages></addata></record>
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identifier ISSN: 0143-3334
ispartof Carcinogenesis (New York), 1990-02, Vol.11 (2), p.333-339
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source Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects 2-Acetylaminofluorene
Aminobiphenyl Compounds - metabolism
Aminobiphenyl Compounds - toxicity
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens
Chemical agents
DNA - metabolism
Hydroxyacetylaminofluorene - metabolism
Hydroxyacetylaminofluorene - toxicity
Liver Neoplasms, Experimental - chemically induced
Male
Medical sciences
Micronuclei, Chromosome-Defective - drug effects
Mutagens
Rats
Rats, Inbred Strains
Tumors
title Correlation between clastogenicity and promotion activity in liver carcinogenesis by N-hydroxy-2-acetylaminofluorene, N-hydroxy-4'-fluoro-4-acetylaminobiphenyl and N-hydroxy-4-acetylaminobiphenyl
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