A conserved idiotype and antibodies to retroviral protein in systemic lupus erythematosus

22 of 61 systemic lupus erythematosus (SLE) patients produced antibodies to the p24 gag protein of HIV-1 demonstrated by Western blotting. 20 of these 22 patients (91%) also express the 4B4 idiotype (Id 4B4) previously identified on a human anti-Sm monoclonal antibody called 4B4. The following point...

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Bibliographic Details
Published in:The Journal of clinical investigation 1990-01, Vol.85 (6), p.1866-1871
Main Authors: Talal, N, Garry, R F, Schur, PH, Alexander, S, Dauphinee, MJ, Livas, I H, Ballester, A, Takei, M, Dang, H
Format: Article
Language:English
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Summary:22 of 61 systemic lupus erythematosus (SLE) patients produced antibodies to the p24 gag protein of HIV-1 demonstrated by Western blotting. 20 of these 22 patients (91%) also express the 4B4 idiotype (Id 4B4) previously identified on a human anti-Sm monoclonal antibody called 4B4. The following points emerge from our studies: (a) SLE patients make antibodies to p24 gag of HIV-1, (b) there is a relationship between immunity to p24 gag and a conserved idiotype, and (c) anti-Sm antibodies can cross-react with p24 gag.
ISSN:0021-9738