Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking

The recently described FMOC/4-AMP technique for rapid continuous solution synthesis of peptides involving coupling by crystalline FMOC amino acid chlorides and deblocking via 4-(aminomethyl)piperidine (4-AMP) has been extended to the synthesis of a varied number of tachykinin peptides.

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Bibliographic Details
Published in:Journal of organic chemistry 1990, Vol.55 (2), p.721-728
Main Authors: Beyermann, Michael, Bienert, Michael, Niedrich, Hartmut, Carpino, Louis A, Sadat-Aalaee, Dean
Format: Article
Language:English
Subjects:
4-(aminomethyl)piperidine
Chemistry
Exact sciences and technology
Organic chemistry
Peptides
Preparations and properties
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Description
Summary:The recently described FMOC/4-AMP technique for rapid continuous solution synthesis of peptides involving coupling by crystalline FMOC amino acid chlorides and deblocking via 4-(aminomethyl)piperidine (4-AMP) has been extended to the synthesis of a varied number of tachykinin peptides.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo00289a056