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Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking

The recently described FMOC/4-AMP technique for rapid continuous solution synthesis of peptides involving coupling by crystalline FMOC amino acid chlorides and deblocking via 4-(aminomethyl)piperidine (4-AMP) has been extended to the synthesis of a varied number of tachykinin peptides.

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Published in:Journal of organic chemistry 1990, Vol.55 (2), p.721-728
Main Authors: Beyermann, Michael, Bienert, Michael, Niedrich, Hartmut, Carpino, Louis A, Sadat-Aalaee, Dean
Format: Article
Language:English
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container_issue 2
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container_title Journal of organic chemistry
container_volume 55
creator Beyermann, Michael
Bienert, Michael
Niedrich, Hartmut
Carpino, Louis A
Sadat-Aalaee, Dean
description The recently described FMOC/4-AMP technique for rapid continuous solution synthesis of peptides involving coupling by crystalline FMOC amino acid chlorides and deblocking via 4-(aminomethyl)piperidine (4-AMP) has been extended to the synthesis of a varied number of tachykinin peptides.
doi_str_mv 10.1021/jo00289a056
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ispartof Journal of organic chemistry, 1990, Vol.55 (2), p.721-728
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source American Chemical Society
subjects 4-(aminomethyl)piperidine
Chemistry
Exact sciences and technology
Organic chemistry
Peptides
Preparations and properties
title Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking
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