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Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking
The recently described FMOC/4-AMP technique for rapid continuous solution synthesis of peptides involving coupling by crystalline FMOC amino acid chlorides and deblocking via 4-(aminomethyl)piperidine (4-AMP) has been extended to the synthesis of a varied number of tachykinin peptides.
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Published in: | Journal of organic chemistry 1990, Vol.55 (2), p.721-728 |
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Language: | English |
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container_end_page | 728 |
container_issue | 2 |
container_start_page | 721 |
container_title | Journal of organic chemistry |
container_volume | 55 |
creator | Beyermann, Michael Bienert, Michael Niedrich, Hartmut Carpino, Louis A Sadat-Aalaee, Dean |
description | The recently described FMOC/4-AMP technique for rapid continuous solution synthesis of peptides involving coupling by crystalline FMOC amino acid chlorides and deblocking via 4-(aminomethyl)piperidine (4-AMP) has been extended to the synthesis of a varied number of tachykinin peptides. |
doi_str_mv | 10.1021/jo00289a056 |
format | article |
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language | eng |
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source | American Chemical Society |
subjects | 4-(aminomethyl)piperidine Chemistry Exact sciences and technology Organic chemistry Peptides Preparations and properties |
title | Rapid continuous peptide synthesis via FMOC amino acid chloride coupling and 4-(aminomethyl)piperidine deblocking |
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