Biocompatibility and degradation mechanisms of predegraded and non-predegraded poly(lactide) implants: an animal study

A comparison is made between the histopathological reaction to non-degraded and predegraded as-polymerized poly (lactide) (PLLA), PLA96 and polyethylene (PE) discs implanted subcutaneously in rats. Based on the chemical analysis, the degradation rate of PLA96 is higher compared with PLLA. The histol...

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Bibliographic Details
Published in:Journal of materials science. Materials in medicine 1995-12, Vol.6 (12), p.715-724
Main Authors: Bergsma, J. E., Rozema, F. R., Bos, R. R. M., van Rozendaal, A. W. M., De Jong, W. H., Teppema, J. S., Joziasse, C. A. P.
Format: Article
Language:English
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Summary:A comparison is made between the histopathological reaction to non-degraded and predegraded as-polymerized poly (lactide) (PLLA), PLA96 and polyethylene (PE) discs implanted subcutaneously in rats. Based on the chemical analysis, the degradation rate of PLA96 is higher compared with PLLA. The histological reaction to non-degraded PLLA and PLA96 discs is very mild. The histological reaction to the predegraded implants is qualitatively similar to the reaction to the non-degraded implants, however, quantitatively an increase is noted. A number of predegraded PLLA and PLA96 discs shows an increase of volume with implantation time cause by the formation of fields of polymer debris accompanied by a granulomatous inflammatory reaction.
ISSN:0957-4530
1573-4838
DOI:10.1007/BF00134307