Human macrophages secrete platelet-activating factor acetylhydrolase

When monocytes mature to macrophages, their ability to accumulate the pro-inflammatory lipid autacoid, platelet-activating factor (PAF), is markedly decreased in conjunction with a 260-fold increase in the activity of intracellular PAF acetylhydrolase (PAF-AH). We now demonstrate that macrophages al...

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Bibliographic Details
Published in:The Journal of biological chemistry 1990-06, Vol.265 (17), p.9682-9687
Main Authors: STAFFORINI, D. M, ELSTAD, M. R, MCINTYRE, T. M, ZIMMERMAN, G. A, PRESCOTT, S. M
Format: Article
Language:English
Subjects:
Exact sciences and technology
Mathematical analysis
Mathematics
Potential theory
Sciences and techniques of general use
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Summary:When monocytes mature to macrophages, their ability to accumulate the pro-inflammatory lipid autacoid, platelet-activating factor (PAF), is markedly decreased in conjunction with a 260-fold increase in the activity of intracellular PAF acetylhydrolase (PAF-AH). We now demonstrate that macrophages also secrete PAF-AH and that the secreted enzyme is biochemically and immunologically identical to the human plasma PAF-AH. The data indicate that macrophages are a cellular source of the plasma PAF-AH. Thus, macrophages secrete an enzyme that inactivates lipid mediators at sites of inflammation and in plasma. These changes during the maturation of monocytes to macrophages may serve to limit the acute inflammatory response.
ISSN:0021-9258
1083-351X