Enhanced intracellular sodium concentration in kidney cells recruits a latent pool of Na-K-ATPase whose size is modulated by corticosteroids

Besides its role in the control of the rate of functioning of each Na-K-ATPase unit (as a substrate of the enzyme), the intracellular sodium concentration also regulates the number of active Na-K-ATPase units, as previously described in cultured cells. To evaluate such a possibility in kidney epithe...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 1990-01, Vol.264 (14), p.7799-7803
Main Authors: Barlet-Bas, C, Khadouri, C, Marsy, S, Doucet, A
Format: Article
Language:English
Subjects:
corticosteroids
kidney
sodium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Besides its role in the control of the rate of functioning of each Na-K-ATPase unit (as a substrate of the enzyme), the intracellular sodium concentration also regulates the number of active Na-K-ATPase units, as previously described in cultured cells. To evaluate such a possibility in kidney epithelial cells, the intracellular concentration of sodium in rat cortical collecting tubules (CCT) maintained in vitro was altered by the use of the sodium ionophore nystatin.
ISSN:0021-9258