Differences in CYP1A Response Between Flounder (Platichthys flesus) and Plaice (Pleuronectes platessa) After Long-Term Exposure to Harbour Dredged Spoil in a Mesocosm Study

In fish, CYP1A protein can be specifically induced by compounds with a planar molecular structure. A microcosm study was conducted to compare CYP1A protein and 7-ethoxyresorufin (EROD) activity in flounder and plaice exposed for extended periods to harbor dredged spoil. No hepatic EROD induction was...

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Bibliographic Details
Published in:Chemosphere (Oxford) 1996-04, Vol.32 (7), p.1357-1357
Main Authors: Eggens, Martin L, Vethaak, ADick, Leaver, Michael J, Horbach, GJMJean, Boon, Jan P, Seinen, Willem
Format: Article
Language:English
Subjects:
Marine
Platichthys flesus
Pleuronectes platessa
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Summary:In fish, CYP1A protein can be specifically induced by compounds with a planar molecular structure. A microcosm study was conducted to compare CYP1A protein and 7-ethoxyresorufin (EROD) activity in flounder and plaice exposed for extended periods to harbor dredged spoil. No hepatic EROD induction was observed in flounder after exposure for up to 24 months, but CYP1A indices were clearly responsive to the contaminants when the fish were injected with one dose of benzo(a)pyrene. However, plaice responded in a time-and dose-related manner, showing increased EROD activity and CYP1A protein content. The overall data suggested that flounder have a relatively low sensitivity to induction by PCBs and/or similar compounds.
ISSN:0045-6535
DOI:10.1016/0045-6535(96)00046-X