Plasma and CSF tryptophan in cancer anorexia

To investigate the role of tryptophan in cancer anorexia, fasting plasma and CSF levels of tryptophan and other neutral amino acids were assayed in patients and controls. Cancer patients showed abnormally high plasma free tryptophan levels. In case of patients with cancer anorexia a significant rise...

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Bibliographic Details
Published in:Journal of Neural Transmission 1990-01, Vol.81 (3), p.225-233
Main Authors: CANGIANO, C, CASCINO, A, CECI, F, LAVIANO, A, MULIERI, M, MUSCARITOLI, M, ROSSI-FANELLI, F
Format: Article
Language:English
Subjects:
Biological and medical sciences
General aspects
Medical sciences
Tumors
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Summary:To investigate the role of tryptophan in cancer anorexia, fasting plasma and CSF levels of tryptophan and other neutral amino acids were assayed in patients and controls. Cancer patients showed abnormally high plasma free tryptophan levels. In case of patients with cancer anorexia a significant rise of the ratio in plasma between free and tryptophan-large neutral amino acids, competing with tryptophan for its brain entry, was observed.
ISSN:0300-9564
1435-1463
DOI:10.1007/BF01245044