Induction and Regulation of NFκB during Aging: Role of Protein Kinases

Aging is accompanied by significant declines in immune function. To understand the basis for this age-related decline we have investigated the induction and regulation of transcription factor NFκB in murine T cells. We report that anti-CD3 treatment of T lymphocytes from old mice resulted in signifi...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1996-04, Vol.79 (1), p.87-91
Main Authors: Trebilcock, Gina Uken, Ponnappan, Usha
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Modulation of the immune response (stimulation, suppression)
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Summary:Aging is accompanied by significant declines in immune function. To understand the basis for this age-related decline we have investigated the induction and regulation of transcription factor NFκB in murine T cells. We report that anti-CD3 treatment of T lymphocytes from old mice resulted in significantly lower levels of NFκB than those observed in similarly treated T cells from young mice. Pretreatment of T cells with staurosporine reduced the induction of NFκB in anti-CD3-activated cells from young mice but had no effect in similarly treated T cells from old mice. However, pretreatment with H-89 had little or no effect on the induction of NFκB in T cells from young mice, but significantly enhanced the induction of NFκB in T cells from old mice. These results suggest that the impairment in the generation of NFκB during aging may reflect age-associated differences in the regulation of protein kinase A.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1996.0054