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Laboratory and field evaluation of deet, CIC-4, and AI3-37220 against Anopheles dirus (Diptera: Culicidae) in Thailand

Laboratory and field tests of the repellents diethyl methylbenzamide (deet), 1-(3-Cyclohexen-l-yl-carbonyl)-2-methylpiperidine (AI3-37220), and (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4) were conducted against Anopheles dirus Peyton and Harrison, the principal malaria vector in Thailand...

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Bibliographic Details
Published in:Journal of medical entomology 1996-07, Vol.33 (4), p.511-515
Main Authors: Frances, S.P. (Army Malaria Research Unit, New South Wales, Australia.), Klein, T.A, Hildebrandt, D.W, Burge, R, Noigamol, C, Eikarat, N, Sripongsai, B, Wirtz, R.A
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Language:English
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Summary:Laboratory and field tests of the repellents diethyl methylbenzamide (deet), 1-(3-Cyclohexen-l-yl-carbonyl)-2-methylpiperidine (AI3-37220), and (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4) were conducted against Anopheles dirus Peyton and Harrison, the principal malaria vector in Thailand. In the laboratory, An. dirus was more sensitive to CIC-4 than either AI3-37220 or deet. The duration of protection provided by each repellent in laboratory tests increased with higher concentrations of repellents and when exposed in cages containing fewer mosquitoes. A field study in Chanthaburi Province, southeastern Thailand, during November 1993 tested 25% (wt:wt) ethanol solutions of each repellent against An. dirus. In contrast to the laboratory experiments, protection provided by AI3-37220 was significantly better than either deet or CIC-4 and there was no significant difference between deet and CIC-4. Protection provided by deet and CIC-4 fell to below 95% 2 h after repellent application, whereas AI3-37220 provided 95% protection for 4 h. The protection provided by all repellents fell to less than or equal to 65% 7 h after repellent application
ISSN:0022-2585
1938-2928
DOI:10.1093/jmedent/33.4.511