Regulation of elemental ratios in affective disorders: A study using PIXE

The biochemical aetiology of affective disorders includes possible derangement of trace-elements metabolism. It is however becoming clear that rather than individual elements, ratios of critical elements might be more important parameters to study. In this work, we have employed a 2 MeV proton beam...

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Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 1996, Vol.117 (1), p.175-178
Main Authors: Ojo, J.O., Oluwole, A.F., Durosinmi, M.A., Asubiojo, O.I.
Format: Article
Language:English
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Summary:The biochemical aetiology of affective disorders includes possible derangement of trace-elements metabolism. It is however becoming clear that rather than individual elements, ratios of critical elements might be more important parameters to study. In this work, we have employed a 2 MeV proton beam PIXE facility to determine the concentrations of up to 9 elements, K, Ca, Fe, Cu, Zn, Br, Rb, S and P, in freeze-dried plasma and erythrocytes obtained from 21 patients suffering from affective disorders. The regulation of some important ratios in terms of dispersion about mean values were studied as well as correlations between these elements. There were very marked close regulations of elemental ratios in affective disorders when the results are compared with those obtained from normal subjects used as controls.
ISSN:0168-583X
1872-9584
DOI:10.1016/0168-583X(96)00236-4