Affinities and intrinsic activities of dopamine receptor agonists for the hD sub(21) and hD sub(4.4) receptors

The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD sub(21) and hD sub(4.4) receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities...

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Bibliographic Details
Published in:European journal of pharmacology 1996-04, Vol.301 (1-3), p.R11-R13
Main Authors: Lahti, R A, Mutin, A, Cochrane, E V, Tepper, P G, Dijkstra, D, Wikstroem, H, Tamminga, CA
Format: Article
Language:English
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Summary:The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD sub(21) and hD sub(4.4) receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine hD sub(21) and hD sub(4.4) receptors, respectively. Affinities also varied. A single, or multiple, dopamine D sub(2)-type receptor(s) may be involved in schizophrenia and agonists are being tested as therapy. Understanding their properties at the individual dopamine D sub(2)-family receptors is important.
ISSN:0014-2999