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TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast
Two systems of transcription factors stimulate expression of the HIS4 gene of Saccharomyces cerevisiae. High-level transcription induced by amino-acid starvation is mediated by Gcn4 (ref. 1) and basal transcription is mediated jointly by the factors Bas1 and Bas2 (Pho2). We now show that wild-type G...
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| Published in: | Nature (London) 1990-11, Vol.348 (6296), p.82-85 |
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| Main Authors: | , , |
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| cites | cdi_FETCH-LOGICAL-c441t-794df1ba71329be9e26e1bf0709c874d27617231a934af60adee7ca44cc70e743 |
| container_end_page | 85 |
| container_issue | 6296 |
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| container_title | Nature (London) |
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| creator | Pellman, D McLaughlin, M.E Fink, G.R |
| description | Two systems of transcription factors stimulate expression of the HIS4 gene of Saccharomyces cerevisiae. High-level transcription induced by amino-acid starvation is mediated by Gcn4 (ref. 1) and basal transcription is mediated jointly by the factors Bas1 and Bas2 (Pho2). We now show that wild-type Gcn4 requires the TATA element for correct messenger RNA start-site selection, but Gcn4 derivatives with deletions in the activation domain activate HIS4 transcription at the correct mRNA start site (I) in the absence of the TATA element. Gcn4 derivatives that activate TATA-independent transcription show low levels of activation. Similarly, we find that low levels of transcription by Bas1/Bas2 are TATA-independent, whereas high levels are TATA-dependent. These results show that the HIS4 TATA element is required for mRNA start-site selection only under conditions of high-level transcription. |
| doi_str_mv | 10.1038/348082a0 |
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High-level transcription induced by amino-acid starvation is mediated by Gcn4 (ref. 1) and basal transcription is mediated jointly by the factors Bas1 and Bas2 (Pho2). We now show that wild-type Gcn4 requires the TATA element for correct messenger RNA start-site selection, but Gcn4 derivatives with deletions in the activation domain activate HIS4 transcription at the correct mRNA start site (I) in the absence of the TATA element. Gcn4 derivatives that activate TATA-independent transcription show low levels of activation. Similarly, we find that low levels of transcription by Bas1/Bas2 are TATA-independent, whereas high levels are TATA-dependent. These results show that the HIS4 TATA element is required for mRNA start-site selection only under conditions of high-level transcription.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/348082a0</identifier><identifier>PMID: 2234066</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Amino acids ; Baking yeast ; Base Sequence ; Binding sites ; Biological and medical sciences ; Cellular biology ; Derivatives ; DNA-Binding Proteins ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - pharmacology ; Gene expression ; genes ; Genes, Fungal - genetics ; Genetics ; HIS4 gene ; Histidine - genetics ; Low level ; Medical research ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Mutation ; nucleotide sequences ; Plasmids ; Promoter Regions, Genetic - genetics ; Protein Kinases ; Proteins ; RNA ; RNA, Messenger - genetics ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae Proteins ; Site selection ; TATA Box - genetics ; transcription (genetics) ; Transcription activation ; Transcription factors ; Transcription Factors - pharmacology ; Transcription initiation ; Transcription, Genetic - drug effects ; Yeasts</subject><ispartof>Nature (London), 1990-11, Vol.348 (6296), p.82-85</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Nov 1, 1990</rights><rights>Copyright Nature Publishing Group Nov 1, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-794df1ba71329be9e26e1bf0709c874d27617231a934af60adee7ca44cc70e743</citedby><cites>FETCH-LOGICAL-c441t-794df1ba71329be9e26e1bf0709c874d27617231a934af60adee7ca44cc70e743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19344567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2234066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pellman, D</creatorcontrib><creatorcontrib>McLaughlin, M.E</creatorcontrib><creatorcontrib>Fink, G.R</creatorcontrib><title>TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Two systems of transcription factors stimulate expression of the HIS4 gene of Saccharomyces cerevisiae. High-level transcription induced by amino-acid starvation is mediated by Gcn4 (ref. 1) and basal transcription is mediated jointly by the factors Bas1 and Bas2 (Pho2). We now show that wild-type Gcn4 requires the TATA element for correct messenger RNA start-site selection, but Gcn4 derivatives with deletions in the activation domain activate HIS4 transcription at the correct mRNA start site (I) in the absence of the TATA element. Gcn4 derivatives that activate TATA-independent transcription show low levels of activation. Similarly, we find that low levels of transcription by Bas1/Bas2 are TATA-independent, whereas high levels are TATA-dependent. 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Psychology</subject><subject>Fungal Proteins - pharmacology</subject><subject>Gene expression</subject><subject>genes</subject><subject>Genes, Fungal - genetics</subject><subject>Genetics</subject><subject>HIS4 gene</subject><subject>Histidine - genetics</subject><subject>Low level</subject><subject>Medical research</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Mutagenesis, Site-Directed</subject><subject>Mutation</subject><subject>nucleotide sequences</subject><subject>Plasmids</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Protein Kinases</subject><subject>Proteins</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>Site selection</subject><subject>TATA Box - genetics</subject><subject>transcription (genetics)</subject><subject>Transcription activation</subject><subject>Transcription factors</subject><subject>Transcription Factors - pharmacology</subject><subject>Transcription initiation</subject><subject>Transcription, Genetic - drug effects</subject><subject>Yeasts</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNp10VFP2zAQB3BrYmKFTeILANHQ0F6yne2rnTxWCAai0h5anqOrc2FBrVPs5KHffoZ2gJD2ZOnupzv7byGOJPyQoIufGgsoFMEHMZJoTY6msHtiBKCKHAptPomDGB8AYCwt7ot9pTSCMSNxO5_MJ3nNa_Y1-z4jX2fPpda_FvtAPrrQrvu28xmlwh_Orm9mmN2z56xrsg1T7D-Ljw0tI3_ZnYfi7upyfnGdT3__urmYTHOHKPvcllg3ckFWalUuuGRlWC4asFC6wmKtrJFWaUmlRmoMUM1sHSE6Z4Et6kNxvp27Dt3jwLGvVm10vFyS526IlRzb4imVBM_ewYduCD7drUoB6FJJpU1SX_-rAFFpayCh71vkQhdj4KZah3ZFYVNJqJ6WVf--INHj3bxhseL6Be4yT_1vuz5FR8smheva-DovPRvHxiZ3snWe-iHwC3iz6HQLGuoqug9pyN1MgdSgLJhxqfRf1FGcqg</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Pellman, D</creator><creator>McLaughlin, M.E</creator><creator>Fink, G.R</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope></search><sort><creationdate>19901101</creationdate><title>TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast</title><author>Pellman, D ; McLaughlin, M.E ; Fink, G.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-794df1ba71329be9e26e1bf0709c874d27617231a934af60adee7ca44cc70e743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino acids</topic><topic>Baking yeast</topic><topic>Base Sequence</topic><topic>Binding sites</topic><topic>Biological and medical sciences</topic><topic>Cellular biology</topic><topic>Derivatives</topic><topic>DNA-Binding Proteins</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Nature (London), 1990-11, Vol.348 (6296), p.82-85 |
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| subjects | Amino acids Baking yeast Base Sequence Binding sites Biological and medical sciences Cellular biology Derivatives DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Fungal Proteins - pharmacology Gene expression genes Genes, Fungal - genetics Genetics HIS4 gene Histidine - genetics Low level Medical research Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis, Site-Directed Mutation nucleotide sequences Plasmids Promoter Regions, Genetic - genetics Protein Kinases Proteins RNA RNA, Messenger - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Site selection TATA Box - genetics transcription (genetics) Transcription activation Transcription factors Transcription Factors - pharmacology Transcription initiation Transcription, Genetic - drug effects Yeasts |
| title | TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast |
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