Metabolic pathways of concanavalin action on chemical sensitivity at the neuronal membrane

Concanavalin A (Co A) has been shown to degress response produced at the membrane of dialyzed snail neurons by acetylcholine (ACh) and gamma -amino-butyric acid (GABA) and blocked by ouabain. The inhibitory effect of Co A on such response was suppressed by lowering the temperature to 5 degree C. Co...

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Bibliographic Details
Published in:Neurophysiology (New York) 1989-09, Vol.21 (5), p.480-486
Main Authors: Arvanov, V. L., Azatyan, K. V., Airapetyan, S. N.
Format: Article
Language:English
Subjects:
Aplysia
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Summary:Concanavalin A (Co A) has been shown to degress response produced at the membrane of dialyzed snail neurons by acetylcholine (ACh) and gamma -amino-butyric acid (GABA) and blocked by ouabain. The inhibitory effect of Co A on such response was suppressed by lowering the temperature to 5 degree C. Co A produced no noticeable effect on ACh-induced response insensitive to ouabain and inhibited ACh-induced outflow of Rb super(+) ( super(86)Rb) from neurons previously enriched by Rb ions. Phosphorylation of neuronal membrane fractions occurred under the action of Co A. It is postulated that cAMP-dependent membrane phosphorylation underlies sensitivity to ACh and GABA at the neuronal membrane.
ISSN:0090-2977
1573-9007
DOI:10.1007/BF01052881