Maintaining a controlled residual growth capacity increases the production of polyhydroxyalkanoate copolymers by Alcaligenes eutrophus

The manner in which copolymer poly(HB-co-HV) production was influenced by different methods of limiting cell proliferation during the production phase was examined. Polymer production was significantly improved in fermentation strategies in which some growth was maintained, either by linear or expon...

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Bibliographic Details
Published in:Biotechnology letters 1996-08, Vol.18 (8), p.937-942
Main Authors: ARAGAO, G. M. F, LINDLEY, N. D, URIBELARREA, J. L, PAREILLEUX, A
Format: Article
Language:English
Subjects:
Alcaligenes eutrophus
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
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Summary:The manner in which copolymer poly(HB-co-HV) production was influenced by different methods of limiting cell proliferation during the production phase was examined. Polymer production was significantly improved in fermentation strategies in which some growth was maintained, either by linear or exponential nitrogen source feeding as compared to cultures in which nitrogen supply was totally interrupted. Improved volumetric productivities were obtained in cultures fed with NH sub(4)OH and the proportion of 3HV incorporated was approximately twofold higher in these cultures. These performance improvements were due to higher specific rates of glucose and propionate consumption in cultures in which true growth capacity was maintained.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF00154625