Strategy for assigning a 'skin notation' : A comment

A criterion based on the comparison of the dermal penetration rate with the pulmonary uptake rate at inhalation exposure levels permissible in the workplace is proposed. The criterion intends to assign a skin notation which indicates the need to prevent skin contamination when systematic effects may...

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Bibliographic Details
Published in:The Annals of occupational hygiene 1996-10, Vol.40 (5), p.611-614
Main Authors: DE COCK, J, HEEDERIK, D, KROMHOUT, H, BOLEIJ, J. S. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Humans
Medical sciences
Occupational Exposure
Pesticides, fertilizers and other agrochemicals toxicology
Skin Absorption
Toxicology
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Summary:A criterion based on the comparison of the dermal penetration rate with the pulmonary uptake rate at inhalation exposure levels permissible in the workplace is proposed. The criterion intends to assign a skin notation which indicates the need to prevent skin contamination when systematic effects may result from percutaneous absorption of the material as a gas, solid or liquid. However, results of a study of the urinary excretion of tetrahydrophtalimide in fruit growers with dermal exposure to captan shows that dermal absorption occurred without the obvious contribution from the respiratory route. This suggests that a skin notation based on an occupational exposure limit for respiratory exposure and exposure of hands and forearms is not applicable.
ISSN:0003-4878
1475-3162
DOI:10.1016/0003-4878(95)00094-1