Importance of tumor-specific cytotoxic CD8 super(+) T-cells in eradication of a large subcutaneous MOPC-315 tumor following low-dose melphalan therapy

We have previously demonstrated that depletion of CD8 super(+) T-cells by the use of a monoclonal anti-Lyt-2.2 antibody abolishes the curative effectiveness of low-dose melphalan (L-phenylalanine mustard; L-PAM) therapy for BALB/c mice bearing a large ( greater than or equal to 20 mm) s.c. MOPC-315...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1990-01, Vol.50 (23), p.7641-7649
Main Authors: Takesue, B Y, Pyle, J M, Mokyr, M B
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have previously demonstrated that depletion of CD8 super(+) T-cells by the use of a monoclonal anti-Lyt-2.2 antibody abolishes the curative effectiveness of low-dose melphalan (L-phenylalanine mustard; L-PAM) therapy for BALB/c mice bearing a large ( greater than or equal to 20 mm) s.c. MOPC-315 tumor and extensive metastases. Here we show that as a consequence of low-dose L-PAM therapy, CD8 super(+) T-cells accumulate in the s.c. tumor nodules of MOPC-315 tumor bearers.
ISSN:0008-5472