Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal epileptogenic region in rat brain measured by in vivo L-band electron spin resonance

In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally....

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Bibliographic Details
Published in:Neuroscience letters 1996-03, Vol.205 (3), p.189-192
Main Authors: Komatsu, Makiko, Hiramatsu, Midori, Yokoyama, Hidekatsu, Willmore, L.James
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antioxidant
Antioxidants - pharmacology
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Cyclic N-Oxides
Disease Models, Animal
Drugs, Chinese Herbal - pharmacology
Electron Spin Resonance Spectroscopy
Epilepsy - chemically induced
Epilepsy - drug therapy
Epilepsy - metabolism
Free Radicals - metabolism
General pharmacology
In vivo
Iron - adverse effects
Iron-induced epileptogenic focus
Male
Medical sciences
Nitroxide radical
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rat head
Rats
Rats, Wistar
Spin Labels
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Summary:In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitroxide radicals in the iron-injected regions at the subacute stage of epileptogenesis was prolonged. The Japanese herbal medicine, sho-saiko-to-go-keishi-ka-shakuyakuto (TJ-960), a compound known to have free radical scavenging activity, inhibited the delay of nitroxide radical decay in the rat cerebrum with an iron-induced epileptic focus following injection of carbamoyl-PROXYL. TJ-960 did not affect the decay of nitroxide radicals in the control rats' brain. These data show that TJ-960 has the scavenging activity for free radicals generated within an iron-induced epileptogenic regions of rat brain.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(96)12412-5