The emergence of ciprofloxacin resistance in Salmonella typhimurium

Ciprofloxacin has been used successfully in the treatment of patients with acute salmonellosis and for the eradication of long term gastrointestinal carriage. We describe here the emergence of ciprofloxacin resistance in Salmonella typhimurium during therapy. Of particular concern was the finding th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1990-08, Vol.26 (2), p.296-298
Main Authors: HOWARD, A. J., JOSEPH, T. D., BLOODWORTH, L. L. O., FROST, JENNIFER A., CHART, HENRIK, ROWE, BERNARD
Format: Article
Language:English
Subjects:
Bacteriophages - growth & development
Ciprofloxacin - therapeutic use
Drug Resistance, Microbial
Humans
Male
Middle Aged
Salmonella typhimurium - drug effects
Salmonella typhimurium - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ciprofloxacin has been used successfully in the treatment of patients with acute salmonellosis and for the eradication of long term gastrointestinal carriage. We describe here the emergence of ciprofloxacin resistance in Salmonella typhimurium during therapy. Of particular concern was the finding that this occurrence was associated with the development of cross resistance to other, unrelated, antibiotics, producing an organism which had a reduced susceptibility to all the drugs commonly used for the treatment of invasive salmonella infections.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/26.2.296