In-vitro activity of teicoplanin and ceftriaxone in combination against pathogens involved in paediatric bone and joint infections

• Published in: Journal of antimicrobial chemotherapy 1996-10, Vol.38 (4), p.713-718
• Main Authors: Lhopital, Sylvie, Bonacorsi, Stéphane, Doit, Catherine, Sandin, Anna, Bingen, Edouard
• Format: Article
• Language: English
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial Infections - drug therapy; Biological and medical sciences; Bone Diseases - drug therapy; Ceftriaxone - therapeutic use; Child, Preschool; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination - therapeutic use; Haemophilus Infections - drug therapy; Haemophilus influenzae; Humans; Infant; Joint Diseases - drug therapy; Medical sciences; Microbial Sensitivity Tests; Penicillin G - therapeutic use; Pharmacology. Drug treatments; Pneumococcal Infections - drug therapy; Staphylococcal Infections - drug therapy; Streptococcus pneumoniae; Teicoplanin - therapeutic use
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/38.4.713

We investigated the combination of teicoplanin and ceftriaxone for its bactericidal activity against Staphylococcus aureus, Haemophilus influenzae type b and Streptococcus pneumoniae isolated from bone and joint infections in children. An increase in bactericidal activity was observed against isolates of S. aureus and H. influenzae when the antibiotics were tested at fractional MICs whereas indifference was observed at their MICs. Similar results were obtained at fractional MICs against S. pneumoniae, but the bactericidal activity fell by more than 1 × log 10 cfu/mL when the antibiotics were tested at or above their MICs.