Pefloxacin in lower respiratory tract infections

To determine the efficacy and safety of pefloxacin in the treatment of lower respiratory tract infections, a multicentre trial involving four departments of respiratory diseases was performed. One hundred and eight patients were admitted to the study. Isolation and identification of responsible micr...

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Bibliographic Details
Main Authors: Grassi, C, Catena, E, de Iola, G, Ginesu, F, Gori, M, Lucchini, M
Format: Conference Proceeding
Language:English
Online Access:Get full text
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Summary:To determine the efficacy and safety of pefloxacin in the treatment of lower respiratory tract infections, a multicentre trial involving four departments of respiratory diseases was performed. One hundred and eight patients were admitted to the study. Isolation and identification of responsible microorganisms from bronchial secretions was possible in 78 patients. Seven patients were withdrawn, one for worsening of the underlying disease and six for early side-effects. Thus, of 108 patients recruited, 101 completed the course of therapy. Of these 43 (42 multiplied by 6%) were cured and 48 (47 multiplied by 5%) showed improvement. Eradication of responsible microorganisms was achieved in 70 (90 multiplied by 9%) of 77 patients microbiologically evaluated. Side-effects of moderate severity were observed in 12 patients (gastrointestinal disturbances in 11 and dyspnoea in one).
ISSN:0305-7453