Behavioural evidence for a functional interaction between central 5-HT sub(2) and 5-HT sub(1A) receptors

The possibility of 5-HT sub(2) receptor modulation of central 5-HT sub(1A) receptor function has been examined using the 5-hydroxytryptamine (5-HT) behavioural syndrome induced by 5-HT sub(1A) receptor active drugs in rats. We suggest that ritanserin, ICI 170,809 and ketanserin enhance 5-HT sub(1A)...

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Bibliographic Details
Published in:British journal of pharmacology 1990-01, Vol.100 (4), p.793-799
Main Authors: Backus, LI, Sharp, T, Grahame-Smith, D G
Format: Article
Language:English
Subjects:
ketanserin
ritanserin
serotonin S1A
serotonin S2
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Summary:The possibility of 5-HT sub(2) receptor modulation of central 5-HT sub(1A) receptor function has been examined using the 5-hydroxytryptamine (5-HT) behavioural syndrome induced by 5-HT sub(1A) receptor active drugs in rats. We suggest that ritanserin, ICI 170,809 and ketanserin enhance 5-HT sub(1A) agonist-induced behavior through blockade of an inhibitory 5-HT sub(2) receptor regulating or coupled to 5-HT sub(1A) receptor-mediated function.
ISSN:0007-1188