Brachial-Ankle Pulse Wave Velocity Is a Strong Predictor for Mortality in Patients With Acute Stroke

Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its predictive value for mortality in patients with acute stroke is u...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-08, Vol.64 (2), p.240-246
Main Authors: Kim, Jinkwon, Song, Tae-Jin, Song, Dongbeom, Lee, Ki Jeong, Kim, Eun Hye, Lee, Hye Sun, Nam, Chung Mo, Nam, Hyo Suk, Kim, Young Dae, Heo, Ji Hoe
Format: Article
Language:English
Subjects:
Aged
Ankle Brachial Index
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity - physiology
Brain Ischemia - mortality
Brain Ischemia - physiopathology
Cardiology. Vascular system
Female
Humans
Male
Medical sciences
Middle Aged
Neurology
Predictive Value of Tests
Prognosis
Pulse Wave Analysis
Severity of Illness Index
Stroke - mortality
Stroke - physiopathology
Vascular diseases and vascular malformations of the nervous system
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Summary:Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its predictive value for mortality in patients with acute stroke is unknown. We evaluated the prognostic value of baPWV in 1765 patients who had been admitted for acute ischemic stroke and had completed measurement of baPWV during admission. Primary outcomes were all-cause mortality and vascular mortality (death because of heart diseases, cerebrovascular diseases, or diseases of arteries, arterioles, and capillaries, determined according to the International Classification of Diseases) after stroke. During a mean follow-up period of 3.33±1.57 years, there were 228 all-cause deaths, including 143 vascular deaths. In multivariate Cox hazard regression, patients in the highest tertile of baPWV (>22.63 m/s) were at an increased risk for both all-cause death (adjusted hazard ratio, 1.97; 95% confidence interval, 1.25–3.08) and vascular death (adjusted hazard ratio, 2.39; 95% confidence interval, 1.33–4.29) compared with the lowest tertile (
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.114.03304