Brachial-Ankle Pulse Wave Velocity Is a Strong Predictor for Mortality in Patients With Acute Stroke

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-08, Vol.64 (2), p.240-246
• Main Authors: Kim, Jinkwon, Song, Tae-Jin, Song, Dongbeom, Lee, Ki Jeong, Kim, Eun Hye, Lee, Hye Sun, Nam, Chung Mo, Nam, Hyo Suk, Kim, Young Dae, Heo, Ji Hoe
• Format: Article
• Language: English
• Subjects: Aged; Ankle Brachial Index; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity - physiology; Brain Ischemia - mortality; Brain Ischemia - physiopathology; Cardiology. Vascular system; Female; Humans; Male; Medical sciences; Middle Aged; Neurology; Predictive Value of Tests; Prognosis; Pulse Wave Analysis; Severity of Illness Index; Stroke - mortality; Stroke - physiopathology; Vascular diseases and vascular malformations of the nervous system
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.114.03304

Brachial-ankle pulse wave velocity (baPWV) has been proposed as a simple, noninvasive method for estimating arterial stiffness. Although high baPWV was predictive of cardiovascular mortality and morbidity among general population, its predictive value for mortality in patients with acute stroke is unknown. We evaluated the prognostic value of baPWV in 1765 patients who had been admitted for acute ischemic stroke and had completed measurement of baPWV during admission. Primary outcomes were all-cause mortality and vascular mortality (death because of heart diseases, cerebrovascular diseases, or diseases of arteries, arterioles, and capillaries, determined according to the International Classification of Diseases) after stroke. During a mean follow-up period of 3.33±1.57 years, there were 228 all-cause deaths, including 143 vascular deaths. In multivariate Cox hazard regression, patients in the highest tertile of baPWV (>22.63 m/s) were at an increased risk for both all-cause death (adjusted hazard ratio, 1.97; 95% confidence interval, 1.25–3.08) and vascular death (adjusted hazard ratio, 2.39; 95% confidence interval, 1.33–4.29) compared with the lowest tertile (