Versican expression in tumor epithelial cells is correlated with a good prognosis in gastric cancer

Versican expression has been reported to have prognostic value in several cancers. The aim of the present study was to investigate the prognostic significance of versican expression in gastric cancer. In total, 105 gastric cancer patients who received gastrectomy were included in the study. Versican...

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Bibliographic Details
Published in:Anticancer research 2014-10, Vol.34 (10), p.5613-5619
Main Authors: Kim, Nam Seok, Lee, Han Hong, Jung, Chan-Kwon, Jeon, Hae Myung
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Gene Expression
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Staging
Patient Outcome Assessment
Prognosis
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Versicans - genetics
Versicans - metabolism
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Summary:Versican expression has been reported to have prognostic value in several cancers. The aim of the present study was to investigate the prognostic significance of versican expression in gastric cancer. In total, 105 gastric cancer patients who received gastrectomy were included in the study. Versican expression in the epithelial and stromal components of the tumors was determined by immunohistochemistry. Versican was expressed in 21.0% of tumor epithelial cells and 44.8% of stromal cells. Patients with versican expression in tumor epithelial cells had significantly better 5-year disease-free (p=0.021) and overall (p=0.034) survival rates, whereas versican expression in stromal cells was not associated with disease-free (p=0.532) and overall (p=0.876) survival. Multivariate analysis showed that versican expression in tumor epithelial cells was an independent prognostic indicator for better clinical outcome in disease-free and overall survival. Versican expression in tumor epithelial cells predicts a good prognosis for gastric cancer patients.
ISSN:1791-7530