Relevance of hyperglycemia on the course and outcome of aneurysmal subarachnoid hemorrhage: evidence and mechanisms

Aneurysmal subarachnoid hemorrhage (aSAH) may have a fatal outcome after a few weeks from ictus, due to its complications, like cerebral vasospasm and edema along with hyperglycemia. Hyperglycemia may be involved in the development of brain vasospasm and edema. It is possible that hyperglycemia play...

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Bibliographic Details
Published in:Investigación clínica 2014-09, Vol.55 (3), p.278-288
Main Author: Pérez-Neri, Iván
Format: Article
Language:Spanish
Subjects:
Brain Edema - etiology
Glucose - metabolism
Humans
Hyperglycemia - complications
Risk Factors
Subarachnoid Hemorrhage - complications
Subarachnoid Hemorrhage - metabolism
Vasospasm, Intracranial - etiology
Vasospasm, Intracranial - prevention & control
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Summary:Aneurysmal subarachnoid hemorrhage (aSAH) may have a fatal outcome after a few weeks from ictus, due to its complications, like cerebral vasospasm and edema along with hyperglycemia. Hyperglycemia may be involved in the development of brain vasospasm and edema. It is possible that hyperglycemia plays a central role in the outcome of aSAH. Several mechanisms may explain this relationship; they include ion balance, excitatory amino acid release, stimulation of vasoconstrictor molecules and reduced synthesis of vasorelaxants. However, some studies do not support this hypothesis regarding the role of hyperglycemia in aSAH. Taken together, the evidence suggests that the control of glucose levels may influence the aSAH outcome depending on the complications that may develop.
ISSN:0535-5133