Incidence and predictive factors for malignancies with dermatomyositis: a cohort from southern China

We aimed to explore the incidence of malignancy in dermatomyositis and assess the potential risk factors of occurrence of malignancy in DM from southern China. A retrospective cohort study of patients admitted in the 1st affiliated university hospital between 2003 and 2012 was performed. Demographic...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2014-09, Vol.32 (5), p.615-621
Main Authors: Chen, Dongying, Yuan, Shiwen, Wu, Xiangni, Li, Hao, Qiu, Qian, Zhan, Zhongping, Ye, Yujin, Lian, Fan, Liang, Liuqin, Xu, Hanshi, Yang, Xiuyan
Format: Article
Language:English
Subjects:
Chi-Square Distribution
China - epidemiology
Comorbidity
Dermatomyositis - diagnosis
Dermatomyositis - epidemiology
Dermatomyositis - mortality
Dermatomyositis - therapy
Early Detection of Cancer
Female
Hospitals, University
Humans
Incidence
Logistic Models
Male
Multivariate Analysis
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - mortality
Neoplasms - therapy
Odds Ratio
Predictive Value of Tests
Prognosis
Retrospective Studies
Risk Factors
Time Factors
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Summary:We aimed to explore the incidence of malignancy in dermatomyositis and assess the potential risk factors of occurrence of malignancy in DM from southern China. A retrospective cohort study of patients admitted in the 1st affiliated university hospital between 2003 and 2012 was performed. Demographic information, clinical symptoms, laboratory findings, medications were documented. The endpoint of the study was defined as occurrence of malignancy or death. For this approximately 10-year retrospective study, 60 out of 246 dermatomyositis patients developed malignancies with the overall incidence of 24.4%. Nasopharyngeal carcinoma (NPC) and ovarian carcinoma were the most common malignant disease, accounting for 35% (21/60) and 15% (9/60) of malignancies, respectively. Lung and colon were followed as the third most common carcinoma (5 out of 60, 8.3%). Among these 60 patients with malignancies, 39 (65.0%, 39/60) cases occurred within 1 year after DM diagnosis. Subsequently, malignancies were detected in 13 (21.7%, 13/60) patients during the second year and 8 (13.3%, 8/60) during the third year. One patient developed cancer at the 35th month after DM as the latest. The logistic regression multivariate analysis indicated that male gender [odds ratio (OR) = 3.76, 95% confidence interval (CI ) 1.86~7.61, p
ISSN:0392-856X