Design of anticoagulant surfaces based on cellulose nanocrystals

The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is d...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (86), p.13070-13072
Main Authors: Ehmann, Heike M A, Mohan, Tamilselvan, Koshanskaya, Maria, Scheicher, Sylvia, Breitwieser, Doris, Ribitsch, Volker, Stana-Kleinschek, Karin, Spirk, Stefan
Format: Article
Language:English
Subjects:
Anticoagulants - chemistry
Anticoagulants - pharmacology
Blood Coagulation - drug effects
Cellulose - chemistry
Heparin - chemistry
Heparin - pharmacology
Humans
Hydrolysis
Nanoparticles - chemistry
Polyethyleneimine - chemistry
Sulfuric Acids - chemistry
Surface Properties
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Summary:The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05254d