Disparate effects of interferon- gamma and tumor necrosis factor- alpha on early neutrophils respiratory burst and fungicidal responses to Candida albicans hyphae in vitro

We examined effect of priming with recombinant human interferon- gamma (IFN) or tumor necrosis factor- alpha (TNF) on neutrophil responses to Candida albicans hyphae. Both cytokines increased early superoxide generation after hyphal stimulation. The more pronounced effects of TNF were accompanied by...

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Bibliographic Details
Published in:The Journal of clinical investigation 1991-01, Vol.87 (2), p.711-720
Main Authors: Diamond, R D, Lyman, CA, Wysong, DR
Format: Article
Language:English
Subjects:
Candida albicans
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Summary:We examined effect of priming with recombinant human interferon- gamma (IFN) or tumor necrosis factor- alpha (TNF) on neutrophil responses to Candida albicans hyphae. Both cytokines increased early superoxide generation after hyphal stimulation. The more pronounced effects of TNF were accompanied by an augmented surface membrane depolarization rate and were insensitive to both pertussis toxin and calcium ion chelation, but were negated by concomitant incubation with puromycin or cycloheximide during priming. Augmentation of early respiratory burst responses to oxidant-sensitive organisms need not necessarily reflect concomitant salutary effects on microbicidal activity.
ISSN:0021-9738