Effects of broad-spectrum monoamine oxidase inhibitors on the structure and ratio of stages in in the cat sleep-wake cycle

Monoamine oxidase (MAO) inhibitors disturb the structure of the sleep-wake cycle and its ultradian rhythms by extending total slow-wave sleep, completely suppressing paradoxical sleep, and reducing total waking period considerably. Once the synchrony induced by MAO inhibitors has stopped, a rebound...

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Bibliographic Details
Published in:Neurophysiology (New York) 1988-07, Vol.20 (4), p.336-342
Main Authors: Akhvlediani, G. R., Oniani, T. N., Gvasaliya, M. G.
Format: Article
Language:English
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Summary:Monoamine oxidase (MAO) inhibitors disturb the structure of the sleep-wake cycle and its ultradian rhythms by extending total slow-wave sleep, completely suppressing paradoxical sleep, and reducing total waking period considerably. Once the synchrony induced by MAO inhibitors has stopped, a rebound effect of increased waking occurs preceding and during partial restoral of paradoxical sleep. Especially marked effects are exerted by MAO inhibitors on paradoxical sleep, in which they produce long-term suppression of tonic and phasic components. It is suggested that inhibition of paradoxical sleep is brought about by selective impairment of functional state of its neurophysiological trigger mechanisms.
ISSN:0090-2977
1573-9007
DOI:10.1007/BF02198441