Suppression of potassium currents by cyanide on the mouse motor nerve terminals

NaCn at low concentrations markedly depressed the potassium currents in the motor nerve terminal of mouse triangularis sterni neuromuscular junction pretreated with potassium channel blockers 4-aminopyridine (4-AP), tetraethylammonium (TEA) or glucose-free medium. Neither azide nor dinitrophenol nor...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 1996-01, Vol.203 (2), p.105-108
Main Authors: Chao, Kuo F., Liu, Shing H., Lin-Shiau, Shoei Y.
Format: Article
Language:English
Subjects:
2,4-Dinitrophenol - pharmacology
4-Aminopyridine - pharmacology
Adenosine Triphosphate - metabolism
Animals
Azides - pharmacology
Cyanide
Enzyme Inhibitors - pharmacology
K + spike
Mice
Mice, Inbred ICR
Motor Endplate - drug effects
Motor nerve
Ouabain - pharmacology
Potassium - metabolism
Potassium Channels - pharmacology
Sodium Azide
Sodium Cyanide - pharmacology
Tetraethylammonium
Tetraethylammonium Compounds - pharmacology
Triangularis sterni
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:NaCn at low concentrations markedly depressed the potassium currents in the motor nerve terminal of mouse triangularis sterni neuromuscular junction pretreated with potassium channel blockers 4-aminopyridine (4-AP), tetraethylammonium (TEA) or glucose-free medium. Neither azide nor dinitrophenol nor ouabain mimicked the effect of cyanide. This inhibitory effect of cyanide on nerve terminal spikes was correlated to its dramatic increase in spontaneous transmitter release under glucose-free condition. These results suggest that the effect of cyanide on the electrogenesis of nerve terminals is due to the direct suppression of ATP-sensitive K + current since the effect was antagonized by ATP-sensitive K + channels opener diazoxide and this may modulate the transmitter release.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(95)12273-7