The relevance of animal neuropathy models for chronic pain in humans

There are currently more than 30 animal models for neuropathic pain. These models are characterized by specific combinations of anomalous nocifensive behavior which suggest the presence of spontaneous pain and abnormal responses to noxious and non-noxious stimuli. Similar disorders are seen in compa...

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Bibliographic Details
Published in:Seminars in the neurosciences 1995-08, Vol.7 (4), p.211-219
Main Author: Seltzer, Ze'ev
Format: Article
Language:English
Subjects:
allodynia
animal models
hyperalgesia
neuropathic pain
nocifensive behavior
sympathetically dependent pain
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Summary:There are currently more than 30 animal models for neuropathic pain. These models are characterized by specific combinations of anomalous nocifensive behavior which suggest the presence of spontaneous pain and abnormal responses to noxious and non-noxious stimuli. Similar disorders are seen in comparable neuropathic pain syndromes. Studies based on these preparations have advanced our understanding of human pain syndromes, and have played a seminal role in several profound conceptual shifts this field has seen in recent decades. These models enable us now to develop better and more specific therapies for neuropathic pain. Especially important is the exciting new research on the prevention of neuropathic pain, which will hopefully lead to diminished prevalence of these ‘pain diseases’ and reduction of their severity.
ISSN:1044-5765
1098-1284
DOI:10.1006/smns.1995.0024