Linkage study of the dopamine D sub(5) receptor gene and Gilles de la Tourette syndrome

A defect in the dopamine system has been hypothesized as the etiological defect in Gilles de la Tourette syndrome (TS). In this report, we test the hypothesis that the dopamine D sub(5) receptor locus (DRD5) is linked to the genetic susceptibility to TS in five families studied in Canada. We tested...

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Bibliographic Details
Published in:American journal of medical genetics 1997-02, Vol.74 (1), p.58-61
Main Authors: Barr, CL, Wigg, K G, Zovko, E, Sandor, P, Tsui, Lap-Chee
Format: Article
Language:English
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Summary:A defect in the dopamine system has been hypothesized as the etiological defect in Gilles de la Tourette syndrome (TS). In this report, we test the hypothesis that the dopamine D sub(5) receptor locus (DRD5) is linked to the genetic susceptibility to TS in five families studied in Canada. We tested for linkage to the dopamine D sub(5) receptor gene using a microsatellite polymorphism located in the same cosmid clone. Using an autosomal dominant model with reduced penetrance, we were able to exclude linkage in four of the five families for the TS and chronic multiple tics (CMT) phenotype. Also, no evidence for linkage was found using nonparametric methods in all five families.
ISSN:0148-7299