Synthesis and antifungal activity of two novel spermidine analogues

Abstract Two spermidine analogues were synthesised and examined for antifungal activity. Both compounds used as 1 mM post-inoculation sprays reduced infection of barley seedlings by the powdery mildew fungus, Erysiphe graminis f.sp. hordei, infection of broad bean seedlings by the rust fungus, Uromy...

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Bibliographic Details
Published in:FEMS microbiology letters 1997-03, Vol.148 (1), p.21-25
Main Authors: Mackintosh, C.A. (Scottish Agricultural Coll., Auchincruive, Ayr (United Kingdom). Dept. of Plant Science), Slater, L.A, McClintock, C.A, Walters, D.R, Havis, N.D, Robins, D.J
Format: Article
Language:English
Subjects:
Airborne microorganisms
Antifungal
Antifungal activity
Antifungal agents
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
ANTIFUNGAL PROPERTIES
AVENA SATIVA
Barley
Biosynthesis
Broad beans
ERYSIPHE GRAMINIS
Erysiphe graminis hordei
ESPERMIDINA
FONGICIDE
Food Microbiology
Fungi
Fungi - drug effects
FUNGICIDAS
Fungicide
FUNGICIDES
Hordeum - microbiology
HORDEUM VULGARE
Infections
Inoculation
Liquid culture
MALUS
Microbiology
Mycelia
Ornithine
Pathogens
PODOSPHAERA LEUCOTRICHA
Polyamines
Powdery mildew
PROPIEDADES ANTIMICOSICAS
PROPRIETE ANTIFONGIQUE
PYRENOPHORA
Pyrenophora avenae
Rosales - microbiology
Rust fungi
Seedlings
SPERMIDINE
Spermidine - analogs & derivatives
Spermidine - chemical synthesis
Spermidine - chemistry
Spermidine analogue
Sprays
UROMYCES VICIAE FABAE
VICIA FABA
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Summary:Abstract Two spermidine analogues were synthesised and examined for antifungal activity. Both compounds used as 1 mM post-inoculation sprays reduced infection of barley seedlings by the powdery mildew fungus, Erysiphe graminis f.sp. hordei, infection of broad bean seedlings by the rust fungus, Uromyces viciae-fabae, and infection of apple seedlings by the powdery mildew fungus, Podosphaera leucotricha. Since these fungal pathogens cannot be cultured axenically, the effects of the two spermidine analogues on mycelial growth in vitro, as well as preliminary investigations on polyamine biosynthesis, were undertaken using the oat stripe pathogen, Pyrenophora avenae. Although neither compound affected radial growth of the fungus on plates, both analogues reduced fungal biomass in liquid culture substantially. The two spermidine analogues, used at a concentration of 1 mM, had no significant effect on the conversion of labelled ornithine into polyamines in P. avenae.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1997.tb10261.x